Sandy Torres
Case Western Reserve University
13 Papers
Sandy Torres is an academic researcher from Case Western Reserve University. The author has contributed to research in topics: Biology & Mitochondrion. The author has an hindex of 9, co-authored 13 publications.
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Papers
Dysregulation of leptin signaling in Alzheimer disease: evidence for neuronal leptin resistance
David J. Bonda,Jeremy G. Stone,Sandy Torres,Sandra L. Siedlak,George Perry,Richard J. Kryscio,Gregory A. Jicha,Gemma Casadesus,Mark A. Smith,Xiongwei Zhu,Hyoung Gon Lee +10 more
TL;DR: These findings are the first to demonstrate such dysregulated leptin‐signaling circuitry and provide novel insights into the possible role of aberrant leptin signaling in AD.
Individual Case Analysis of Postmortem Interval Time on Brain Tissue Preservation
Jeffrey A. Blair,Chunyu Wang,Chunyu Wang,Damarys Hernandez,Sandra L. Siedlak,Mark S. Rodgers,Rojan K. Achar,Lara M. Fahmy,Sandy Torres,Robert B. Petersen,Xiongwei Zhu,Gemma Casadesus,Hyoung Gon Lee +12 more
TL;DR: Human hippocampal segments from the same individuals were sampled at different time points after autopsy creating a series of PMIs for each case, suggesting antemortem factors may play a larger role than PMI in protein and nucleic acid integrity.
Neuronal Mitochondria Modulation of LPS-Induced Neuroinflammation.
TL;DR: The results reveal an unrecognized possible role of neuronal mitochondria in the regulation of microglial activation, and propose neuronal Mfn2 as a likely mechanistic linker between neuron mitochondria dysfunction and neuroinflammation in neurodegeneration.
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Mfn2 Ablation in the Adult Mouse Hippocampus and Cortex Causes Neuronal Death.
Song Han,Priya Nandy,Quillan Austria,Sandra L. Siedlak,Sandy Torres,Hisashi Fujioka,Wenzhang Wang,Xiongwei Zhu +7 more
TL;DR: It is demonstrated that Mfn2 ablation and mitochondrial fragmentation in adult neurons cause neurodegeneration through oxidative stress and neuroinflammation in vivo via both apoptosis and aberrant cell-cycle-event-dependent cell death pathways.
The role of Mfn2 in the structure and function of endoplasmic reticulum-mitochondrial tethering in vivo
Song Han,Song Han,Fanpeng Zhao,Jeffrey Hsia,Xiaopin Ma,Yi Liu,Sandy Torres,Hisashi Fujioka,Xiongwei Zhu +8 more
TL;DR: In this paper, the role of Mfn2 in the formation of mitochondria-endoplasmic reticulum contacts was investigated in pyramidal neurons of hippocampus in Mf2 conditional knockout mice and in Mlf2 overexpressing mice.
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