Sandro Sieber
University of Basel
20 Papers
16 Citations
Sandro Sieber is an academic researcher from University of Basel. The author has contributed to research in topics: In vivo & Drug delivery. The author has an hindex of 11, co-authored 19 publications.
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Papers
PEG-PCL-based nanomedicines: A biodegradable drug delivery system and its application.
TL;DR: This review discusses state‐of‐the‐art nanomedicines based on PEG‐PCL that have been investigated in a preclinical setting and highlights recent therapeutic applications investigated in vitro and in vivo using advanced systems such as triggered release, multi‐component therapies, theranostics, or gene delivery systems.
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Zebrafish as a preclinical in vivo screening model for nanomedicines
Sandro Sieber,Philip Grossen,Jeroen Bussmann,Frederick Campbell,Alexander Kros,Dominik Witzigmann,Dominik Witzigmann,Jörg Huwyler +7 more
TL;DR: Several advantageous features of the zebrafish model, such as biological conservation, imaging modalities, availability of genetic tools and disease models, as well as their various applications in nanomedicine development, are outlined.
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Biomimetic artificial organelles with in vitro and in vivo activity triggered by reduction in microenvironment
Tomaz Einfalt,Dominik Witzigmann,Christoph Edlinger,Sandro Sieber,Roland Goers,Roland Goers,Adrian Najer,Mariana Spulber,Ozana Onaca-Fischer,Jörg Huwyler,Cornelia G. Palivan +10 more
TL;DR: These biomimetic AOs are functional in vivo in zebrafish embryos, which demonstrates the feasibility of using AOs as cellular implants in living organisms and opens new perspectives for patient-oriented protein therapy.
Zebrafish as an early stage screening tool to study the systemic circulation of nanoparticulate drug delivery systems in vivo
Sandro Sieber,Philip Grossen,Pascal Detampel,Salome Siegfried,Dominik Witzigmann,Jörg Huwyler +5 more
TL;DR: The findings indicate that the zebrafish model is a useful vertebrate screening tool for nanoparticulate drug delivery systems to predict their in vivo circulation behavior with respect to systemic circulation time and exposure.
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Rapid optimization of liposome characteristics using a combined microfluidics and design-of-experiment approach
Mahsa Sedighi,Sandro Sieber,Fereshteh Rahimi,Mohammad-Ali Shahbazi,Ali Hossein Rezayan,Jörg Huwyler,Dominik Witzigmann,Dominik Witzigmann +7 more
TL;DR: This study indicates that a microfluidics-based formulation approach combined with DoE is suitable for the routine development of monodisperse and size-specific liposomes in a reproducible and rapid manner.
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