Sandrine Lépine
Virginia Commonwealth University
11 Papers
234 Citations
Sandrine Lépine is an academic researcher from Virginia Commonwealth University. The author has contributed to research in topics: Ceramide & Sphingosine. The author has an hindex of 10, co-authored 11 publications. Previous affiliations of Sandrine Lépine include University of Paris.
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Papers
Involvement of Sphingosine Kinase 2 in p53-Independent Induction of p21 by the Chemotherapeutic Drug Doxorubicin
Heidi Sankala,Nitai C. Hait,Steven W. Paugh,Dai Shida,Sandrine Lépine,Lynne W. Elmore,Paul Dent,Sheldon Milstien,Sarah Spiegel +8 more
TL;DR: The results show that endogenous SphK2 is important for p53-independent induction of p21 expression by doxorubicin and suggest that SphK 2 may influence the balance between cytostasis and apoptosis of human cancer cells.
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Cross-talk between LPA1 and Epidermal Growth Factor Receptors Mediates Up-regulation of Sphingosine Kinase 1 to Promote Gastric Cancer Cell Motility and Invasion
Dai Shida,Xianjun Fang,Tomasz Kordula,Kazuaki Takabe,Sandrine Lépine,Sergio E. Alvarez,Sheldon Milstien,Sarah Spiegel +7 more
TL;DR: The results suggest that SphK1 is a convergence point of multiple cell surface receptors for three different ligands, LPA, EGF, and S1P, which have all been implicated in regulation of motility and invasiveness of cancer cells.
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Autophagy induced by deficiency of sphingosine-1-phosphate phosphohydrolase 1 is switched to apoptosis by calpain-mediated autophagy-related gene 5 (Atg5) cleavage.
TL;DR: Doxorubicin treatment switches protective autophagy in sphingosine-1-phosphate phosphohydrolase-1 (SPP1)-depleted cells to apoptosis, increasing ceramide synthesis that enhances calpain activation and cleavage of pro-autophagic Atg5, generating a pro-apoptotic fragment.
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Sphingosine contributes to glucocorticoid-induced apoptosis of thymocytes independently of the mitochondrial pathway.
Sandrine Lépine,Boris Lakatoš,Marie-Pierre Courageot,Hervé Le Stunff,Jean-Claude Sulpice,Françoise Giraud +5 more
TL;DR: Data indicate that DX-induced apoptosis is mediated in part by SP, which contributes, together with proteasome activity, to caspase-8-3 processing independently of mitochondria, and in partBy the proteasomesome/mitochondria pathway, although independently of caspasing-9 activation.
Innate immune agonist, dsRNA, induces apoptosis in ovarian cancer cells and enhances the potency of cytotoxic chemotherapeutics
Danielle N. Van,Charlotte Roberts,James D. Marion,Sandrine Lépine,Kuzhuvelil B. Harikumar,Jessica Schreiter,Catherine I. Dumur,Xianjun Fang,Sarah Spiegel,Jessica K. Bell +9 more
TL;DR: Using agonists, antagonists, and shRNA‐mediated knockdown of dsRNA receptors, it is shown that TLR3, RIG‐I, and mda5 coordinated a caspase 8/9‐ and interferon‐dependent cell death that induces apoptosis in ovarian cancer cells and enhances the potency of cytotoxic chemotherapeutics.
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