Sandra Ussat
University of Kiel
14 Papers
175 Citations
Sandra Ussat is an academic researcher from University of Kiel. The author has contributed to research in topics: Caspase & Apoptosis. The author has an hindex of 12, co-authored 14 publications.
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Papers
Sensitization to death receptor cytotoxicity by inhibition of fas-associated death domain protein (FADD)/caspase signaling. Requirement of cell cycle progression.
TL;DR: It is reported that in NIH3T3 cells, apoptosis in response TNF and cycloheximide is not inhibited by the broad spectrum caspase inhibitor benzyloxycarbonyl-Val-Ala-Asp-fluoromethyl ketone (zVAD.fmk).
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Differential but Direct Abolishment of Human Regulatory T Cell Suppressive Capacity by Various TLR2 Ligands
TL;DR: The data suggest that a downregulation of p27Kip1 and restoration of Akt phosphorylation in human Tregs pretreated with TLR2 ligands result in a reversal of suppression on responder T cells, and indicate that a mixture of TLR 2 ligands can be used to modulate human T Reg activity.
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Inhibition of p38 mitogen-activated protein kinase reduces TNF-induced activation of NF-κB, elicits caspase activity, and enhances cytotoxicity
TL;DR: It is demonstrated that pharmacological inhibition of p38 MAPK enhances TNF-induced cell death in murine fibroblast cell lines L929 and NIH3T3 and that the nuclear factor kappaB (NF-kappaB)-dependent gene expression was reduced by p38MAPK inhibition.
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Caspase Inhibition Blocks Human T Cell Proliferation by Suppressing Appropriate Regulation of IL-2, CD25, and Cell Cycle-Associated Proteins
TL;DR: It is shown that proliferation of human T cells in response to a specific antigenic stimulus is completely prevented by caspase inhibition, and this lack of proliferation is due to a failure to initiate cell cycle progression, but not the result of increased T cell death.
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Interaction with XIAP prevents full caspase-3/-7 activation in proliferating human T lymphocytes.
Maren Paulsen,Sandra Ussat,Marten Jakob,Gudrun Scherer,Inga Lepenies,Stefan Schütze,Dieter Kabelitz,Sabine Adam-Klages +7 more
TL;DR: It is provided evidence that during T cell proliferation the intracellular caspase inhibitor X‐linked inhibitor‐of‐apoptosis protein (XIAP) interacts with caspases‐3/‐7, thereby blocking their full activation, substrate cleavage, and cell death.
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