Sandra Trindade
Instituto de Medicina Molecular
7 Papers
2 Citations
Sandra Trindade is an academic researcher from Instituto de Medicina Molecular. The author has contributed to research in topics: Adipose tissue & Trypanosoma brucei. The author has an hindex of 4, co-authored 7 publications.
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Papers
Trypanosoma brucei Parasites Occupy and Functionally Adapt to the Adipose Tissue in Mice.
Sandra Trindade,Filipa Rijo-Ferreira,Filipa Rijo-Ferreira,Filipa Rijo-Ferreira,Tânia Carvalho,Daniel Pinto-Neves,Fabien Guegan,Francisco Aresta-Branco,Fabio Bento,Simon A. Young,Andreia Pinto,Jan Van Den Abbeele,Jan Van Den Abbeele,Ruy M. Ribeiro,Ruy M. Ribeiro,Sergio Dias,Terry K. Smith,Luisa M. Figueiredo +17 more
TL;DR: It is discovered that adipose tissue constitutes a third major reservoir for T. brucei during its mammalian life cycle and could potentially explain the weight loss associated with sleeping sickness.
352
Do Cryptic Reservoirs Threaten Gambiense-Sleeping Sickness Elimination?
Philippe Büscher,Jean-Mathieu Bart,Marleen Boelaert,Bruno Bucheton,Giuliano Cecchi,Nakul Chitnis,Nakul Chitnis,David Courtin,Luisa M. Figueiredo,José-Ramon Franco,Pascal Grébaut,Epco Hasker,Hamidou Ilboudo,Vincent Jamonneau,Mathurin Koffi,Veerle Lejon,Annette MacLeod,Justin Masumu,Enock Matovu,Raffaele C. Mattioli,Harry Noyes,Albert Picado,Kat S. Rock,Brice Rotureau,Gustave Simo,Sophie Thevenon,Sandra Trindade,Philippe Truc,Nick Van Reet +28 more
TL;DR: It is argued that a better understanding of the contribution of human and putative animal reservoirs to gambiense-HAT epidemiology is mandatory to inform elimination strategies.
176
Tissue tropism in parasitic diseases.
TL;DR: Current knowledge of tissue tropism in Trypanosoma infections in mammals is discussed, potential mechanisms of tissue entry are described, relevant findings from other parasitology fields are discussed, and new questions raised by recent discoveries are reflected.
79
Trypanosoma brucei triggers a broad immune response in the adipose tissue
Henrique Machado,Tiago Bizarra-Rebelo,Mariana Costa-Sequeira,Sandra Trindade,Tânia Carvalho,Filipa Rijo-Ferreira,Barbara Rentroia-Pacheco,Karine Serre,Luisa M. Figueiredo +8 more
TL;DR: In this paper, the authors found that T. brucei infection triggers a broad and robust immune response in the AT, which requires the complement system to locally reduce parasite burden.