Sandra S. Diebold
King's College London
44 Papers
481 Citations
Sandra S. Diebold is an academic researcher from King's College London. The author has contributed to research in topics: Immune system & Dendritic cell. The author has an hindex of 29, co-authored 42 publications. Previous affiliations of Sandra S. Diebold include National Institute for Biological Standards and Control & Lincoln's Inn.
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Papers
Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA.
TL;DR: These results identify ssRNA as a ligand for TLR7 and suggest that cells of the innate immune system sense endosomal ssRNA to detect infection by RNA viruses.
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Toll-like receptor 3 promotes cross-priming to virus-infected cells
Oliver Schulz,Sandra S. Diebold,Margaret Chen,Tanja I. Näslund,Martijn A. Nolte,Lena Alexopoulou,Lena Alexopoulou,Yasu-Taka Azuma,Richard A. Flavell,Peter Liljeström,Caetano Reis e Sousa +10 more
TL;DR: It is shown that murine CD8α+ dendritic cells are activated by double-stranded (ds)RNA present in virally infected cells but absent from uninfected cells, which indicates that TLR3 may have evolved to permit cross-priming of CTLs against viruses that do not directly infect dendedritic cells.
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Nr4a1-dependent Ly6C(low) monocytes monitor endothelial cells and orchestrate their disposal.
Leo M. Carlin,Efstathios G. Stamatiades,Cédric Auffray,Richard N. Hanna,Leanne Glover,Gema Vizcay-Barrena,Catherine C. Hedrick,H. Terence Cook,Sandra S. Diebold,Frederic Geissmann,Frederic Geissmann +10 more
TL;DR: Ly6Clow monocytes are intravascular housekeepers that orchestrate the necrosis by neutrophils of endothelial cells that signal a local threat sensed via TLR7 followed by the in situ phagocytosis of cellular debris.
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Toll-like receptor expression in murine DC subsets: lack of TLR7 expression by CD8 alpha+ DC correlates with unresponsiveness to imidazoquinolines.
Alexander D. Edwards,Sandra S. Diebold,Emma Slack,Hideyuki Tomizawa,Hiroaki Hemmi,Tsuneyasu Kaisho,Shizuo Akira,Caetano Reis e Sousa +7 more
TL;DR: It is reported that mRNA for most TLR is expressed at similar levels by murine splenic DC sub‐types, including PDC, but that TLR3 is preferentially expressed by CD8α+ DC while TLR5 and TLR7 are selectively absent from the same subset, suggesting that the dichotomy in TLR expression between plasmacytoid and non‐plasmacy toid DC is not conserved between species.
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Nucleic acid agonists for Toll‐like receptor 7 are defined by the presence of uridine ribonucleotides
Sandra S. Diebold,Catherine Massacrier,Shizuo Akira,Carine Paturel,Yannis Morel,Caetano Reis e Sousa +5 more
TL;DR: The results support the notion that TLR7 recognises uracil repeats in RNA and that it discriminates between viral and self ligands on the basis of endosomal accessibility rather than sequence.
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