Sandipkumar Darji
Nathan Kline Institute for Psychiatric Research
17 Papers
33 Citations
Sandipkumar Darji is an academic researcher from Nathan Kline Institute for Psychiatric Research. The author has contributed to research in topics: Autophagy & Medicine. The author has an hindex of 7, co-authored 11 publications. Previous affiliations of Sandipkumar Darji include New York Methodist Hospital & Georgia Regents University.
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Papers
Lysosomal Dysfunction in Down Syndrome Is APP-Dependent and Mediated by APP-βCTF (C99).
Ying Jiang,Yutaka Sato,Eunju Im,Martin J. Berg,Matteo Bordi,Matteo Bordi,Sandipkumar Darji,Asok Kumar,Panaiyur S. Mohan,Urmi Bandyopadhyay,Antonio Diaz,Ana Maria Cuervo,Ralph A. Nixon +12 more
TL;DR: It is reported that lysosomal dysfunction in Down ayndrome (trisomy 21), a neurodevelopmental disorder and form of early onset AD, requires the extra gene copy of amyloid precursor protein (APP) and is specifically mediated by the β cleaved carboxy terminal fragment of APP (APP-βCTF, C99).
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Endosomal Dysfunction Induced by Directly Overactivating Rab5 Recapitulates Prodromal and Neurodegenerative Features of Alzheimer's Disease.
Anna Pensalfini,Anna Pensalfini,Seonil Kim,Seonil Kim,Shivakumar Subbanna,Cynthia Bleiwas,Chris N. Goulbourne,Philip Stavrides,Ying Jiang,Ying Jiang,Ju-Hyun Lee,Ju-Hyun Lee,Sandipkumar Darji,Monika Pawlik,Chunfeng Huo,James Peddy,Martin J. Berg,John F. Smiley,Balapal S. Basavarajappa,Ralph A. Nixon +19 more
TL;DR: Aberrant neuronal Rab5-endosome signaling drives a pathogenic cascade distinct from β-amyloid-related neurotoxicity, which includes prodromal and neurodegenerative features of AD, and suggests Rab5 overactivation as a potential therapeutic target.
β2-adrenergic Agonists Rescue Lysosome Acidification and Function in PSEN1 Deficiency by Reversing Defective ER-to-lysosome Delivery of ClC-7.
Ju-Hyun Lee,Ju-Hyun Lee,Devin M. Wolfe,Sandipkumar Darji,Mary Kate McBrayer,Daniel J. Colacurcio,Asok Kumar,Philip Stavrides,Panaiyur S. Mohan,Ralph A. Nixon,Ralph A. Nixon +10 more
TL;DR: It is reported that isoproterenol and related β2-adrenergic agonists re-acidify lysosomes in PSEN1 KO cells and fibroblasts from PSen1 familial AD(FAD) patients, which restores lysOSomal proteolysis, calcium homeostasis, and normal autophagy flux.
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HV1 Acts as a Sodium Sensor and Promotes Superoxide Production in Medullary Thick Ascending Limb of Dahl Salt-Sensitive Rats
Chunhua Jin,Jingping Sun,Carly A. Stilphen,Susan M.E. Smith,Hiram Ocasio,Brent Bermingham,Sandipkumar Darji,Avirup Guha,Roshan Patel,Aron M. Geurts,Howard J. Jacob,Nevin A. Lambert,Paul M. O'Connor +12 more
TL;DR: It is concluded that HV1 is expressed in medullary thick ascending limb and promotes superoxide production in this segment when intracellular Na+ is low and contributes to the development of hypertension and renal disease in Dahl salt-sensitive rats.
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P4-692: EFFECTS OF P38α MAP KINASE INHIBITION ON THE NEURODEGENERATIVE PHENOTYPE OF THE TS2 DOWN SYNDROME MOUSE MODEL
Ying Jiang,Ying Jiang,Philip Stavrides,Sandipkumar Darji,Dun-Sheng Yang,Dun-Sheng Yang,Cynthia Bleiwas,John F. Smiley,John F. Smiley,Ursula Germann,John Alam,Ralph A. Nixon,Ralph A. Nixon +12 more
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