Sana Emberesh
Cincinnati Children's Hospital Medical Center
5 Papers
Sana Emberesh is an academic researcher from Cincinnati Children's Hospital Medical Center. The author has contributed to research in topics: Congenital dyserythropoietic anemia & Erythropoiesis. The author has an hindex of 3, co-authored 4 publications.
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Papers
Peroxiredoxin II ( PRDX2 ) Is a Novel Candidate Gene for Congenital Dyserythropoietic Anemia
Myesa Emberesh,Katie Giger Seu,Sana Emberesh,Lisa Trump,Mary Risinger,Wenying Zhang,Ammar Husami,Carolyn Lutzko,Vinod Gidvani-Diaz,Robert B. Lorsbach,Theodosia A. Kalfa +10 more
TL;DR: The aim of this work is to validate the pathogenetic role of the PRDX2 variant found in this family as the molecular cause of this dominantly-inherited CDA and further investigate the role ofPRDX2 in human terminal erythropoiesis.
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De Novo Germline DHX38 Variant Associated with Alternative Splicing of Multiple Transcripts in Iron-Related Pathways in a Patient with Atypical Congenital Dyserythropoietic Anemia with Ring Sideroblasts
Aikaterini Voulgaridou,Yasmin Elgammal,Ammar Husami,Sana Emberesh,Katie Giger Seu,Mahesh Ramamoorthy,Lisa Trump,Nathaniel Barasa,Adam S. Nelson,Robert B. Lorsbach,Laurel Romano,Nathan A. Salomonis,Wenying Zhang,Carolyn Lutzko,Theodosia A. Kalfa +14 more
TL;DR: A 2-year-old female, enrolled in CDAR, had transfusion-dependent anemia since birth and had failure to thrive despite regular transfusions maintaining trough hemoglobin higher than 9.5 g/dL as mentioned in this paper .
VPS4A Mutations in Humans Cause Syndromic Congenital Dyserythropoietic Anemia due to Cytokinesis and Trafficking Defects
Katie G. Seu,Lisa Trump,Sana Emberesh,Robert B. Lorsbach,Clarissa E. Johnson,Jessica Meznarich,Hunter R. Underhill,Stella T. Chou,Haripriya Sakthivel,Nicolas Nassar,Kalani J. Seu,Lionel Blanc,Wenying Zhang,Carolyn Lutzko,Theodosia A. Kalfa,Theodosia A. Kalfa +15 more
TL;DR: It is demonstrated that VPS4A mutations cause cytokinesis and trafficking defects leading to a human disease with detrimental effects to erythropoiesis and neurodevelopment, and proband-derived induced pluripotent stem cells have successfully modeled the hematologic aspects of this syndrome in vitro.
Virus-specific T cells for adenovirus infection after stem cell transplantation are highly effective and class II HLA restricted.
Jeremy D. Rubinstein,Xiang Zhu,Thomas Leemhuis,Giang Pham,Lorraine Ray,Sana Emberesh,Sonata Jodele,Sonata Jodele,Shawn Thomas,Jose A. Cancelas,Jose A. Cancelas,Jose A. Cancelas,Catherine M. Bollard,Patrick J. Hanley,Michael D. Keller,Olivia Grimley,Diana Clark,Teri Clark,Cecilia S. Lindestam Arlehamn,Alessandro Sette,Alessandro Sette,Stella M. Davies,Stella M. Davies,Adam S. Nelson,Adam S. Nelson,Michael Grimley,Michael Grimley,Carolyn Lutzko,Carolyn Lutzko +28 more
TL;DR: In this paper, the authors used ex vivo-generated virus-specific T cells (VSTs) for the management of adenoviral infection in immunocompromised hosts.
Neutrophils Derived from Genetically Modified Human Induced Pluripotent Stem Cells Circulate and Phagocytose Bacteria In Vivo
Lisa Trump,Ramesh C. Nayak,Abhishek Singh,Abhishek Singh,Sana Emberesh,Ashley M Wellendorf,Carolyn Lutzko,Carolyn Lutzko,Jose A. Cancelas,Jose A. Cancelas +9 more
TL;DR: In a model of bacterial induced peritonitis in immunodeficient mice, iPSC‐derived neutrophils, with or without corrected AKT activation, migrate similarly to the peritoneal fluid as peripheral blood neutrophil, whereas the expression of activated AKT significantly improves their phagocytic activity in vivo.