35 Papers
413 Citations
Samuel Stone is an academic researcher from National Institute for Occupational Safety and Health. The author has contributed to research in topics: Inhalation exposure & Welding. The author has an hindex of 21, co-authored 33 publications.
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Papers
Pulmonary Nanoparticle Exposure Disrupts Systemic Microvascular Nitric Oxide Signaling
Timothy R. Nurkiewicz,Dale W. Porter,Dale W. Porter,Ann F. Hubbs,Samuel Stone,Bean T. Chen,David G. Frazer,David G. Frazer,Matthew A. Boegehold,Vincent Castranova +9 more
TL;DR: Results indicate that in conjunction with microvascular dysfunction, nanoparticle exposure also decreases NO bioavailability through at least two functionally distinct mechanisms that may mutually increase local reactive species and endogenous nitric oxide.
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Effect of short-term stainless steel welding fume inhalation exposure on lung inflammation, injury, and defense responses in rats.
James M. Antonini,Samuel Stone,Jenny R. Roberts,Bean Chen,Diane Schwegler-Berry,Aliakbar Afshari,David G. Frazer +6 more
TL;DR: Short-term exposure of rats to SS welding fume caused significant lung damage and suppressed lung defense responses to bacterial infection, but had a delayed effect on pulmonary inflammation.
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Design, Construction, and Characterization of a Novel Robotic Welding Fume Generator and Inhalation Exposure System for Laboratory Animals
James M. Antonini,Aliakbar Afshari,Samuel Stone,Bean Chen,Diane Schwegler-Berry,W. Gary Fletcher,W. Travis Goldsmith,Kurt H. Vandestouwe,Walter McKinney,Vincent Castranova,David G. Frazer +10 more
TL;DR: With the development of this novel system, it will be possible to establish an animal model using controlled welding exposures from automated gas metal arc and flux-cored arc welding processes to investigate how welding fumes affect health.
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Comparison of stainless and mild steel welding fumes in generation of reactive oxygen species
Stephen S. Leonard,Bean T. Chen,Samuel Stone,Diane Schwegler-Berry,Allison Kenyon,David G. Frazer,James M. Antonini +6 more
TL;DR: The results suggest that welding fumes may cause acute lung injury and the type of fume generated, particle size, and elapsed time after generation of the welding exposure are significant factors in radical generation and particle deposition these factors should be considered when developing protective strategies.
Pulmonary particulate matter and systemic microvascular dysfunction.
Timothy R. Nurkiewicz,Dale W. Porter,Ann F. Hubbs,Samuel Stone,A. M. Moseley,Jared L. Cumpston,Adam G. Goodwill,Stephanie J. Frisbee,Perrotta Pl,Robert W. Brock,Jefferson C. Frisbee,M.A. Boegehold,D. G. Frazer,Bean Chen,Castranova +14 more
- 01 Dec 2011
TL;DR: Whether particle size affects the severity of postexposure microvascular dysfunction and whether circulating inflammatory mediators, leukocytes, neurologic mechanisms, or a combination of these play a fundamental role in mediating pulmonary PM exposure and peripheral microv vascular dysfunction is determined.
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