Samuel Hertig
Stanford University
7 Papers
Samuel Hertig is an academic researcher from Stanford University. The author has contributed to research in topics: Fibronectin & Allosteric regulation. The author has an hindex of 7, co-authored 7 publications. Previous affiliations of Samuel Hertig include University of California, San Francisco & California Institute for Quantitative Biosciences.
Chat about Author
Papers
Stretching fibronectin fibres disrupts binding of bacterial adhesins by physically destroying an epitope
TL;DR: It is shown using binding assays and steered molecular dynamics that mechanical tension along fibronectin (Fn) fibres causes a structural mismatch between Fn-binding proteins from Streptococcus dysgalactiae and Staphylococcus aureus.
Cryptic pocket formation underlies allosteric modulator selectivity at muscarinic GPCRs
Scott A. Hollingsworth,Scott A. Hollingsworth,Brendan Kelly,Celine Valant,Jordan Arthur Michaelis,Olivia Mastromihalis,Geoff Thompson,AJ Venkatakrishnan,Samuel Hertig,Peter J. Scammells,Patrick M. Sexton,Christian C. Felder,Arthur Christopoulos,Ron O. Dror +13 more
TL;DR: It is shown that positive allosteric modulators of the M1 muscarinic acetylcholine receptor (mAChR) achieve exquisite selectivity by occupying a dynamic pocket absent in existing crystal structures, identified using molecular dynamics simulations.
Novel peptide probes to assess the tensional state of fibronectin fibers in cancer.
Simon Arnoldini,Alessandra Moscaroli,Mamta Chabria,Manuel Hilbert,Samuel Hertig,Roger Schibli,Roger Schibli,Martin Béhé,Viola Vogel +8 more
TL;DR: A new nanoprobe is introduced to assess the mechanical strain of fibronectin (Fn) fibers in tissue, based on the bacterial Fn-binding peptide FnBPA5, that binds to relaxed fibronsectin fibrils and detects relaxed matrix in cell culture, tissue slices and in vivo.
Engineering Mechanosensitive Multivalent Receptor–Ligand Interactions: Why the Nanolinker Regions of Bacterial Adhesins Matter
TL;DR: Functional sequence alignment of bacterial adhesins reveals that the bacterial linkers connecting the multivalent binding motifs recognizing fibronectin show considerable heterogeneity in length, which has potential applications in probing extracellular matrix fiber strains in tissues.
28
Multidomain Assembler (MDA) Generates Models of Large Multidomain Proteins.
TL;DR: MDA automates the tasks of template searching, visualization, and selection followed by multidomain model generation, and is part of the widely used molecular graphics package UCSF CHIMERA (University of California, San Francisco).
20