Samuel Heron
University of Edinburgh
7 Papers
68 Citations
Samuel Heron is an academic researcher from University of Edinburgh. The author has contributed to research in topics: Regulation of gene expression & RNA. The author has an hindex of 4, co-authored 5 publications.
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Papers
Neurons and neuronal activity control gene expression in astrocytes to regulate their development and metabolism.
Philip Hasel,Owen Dando,Owen Dando,Zoeb Jiwaji,Paul Baxter,Alison C Todd,Samuel Heron,Nóra M. Márkus,Jamie McQueen,David W. Hampton,Megan Torvell,Sachin S. Tiwari,Sean McKay,Abel Eraso-Pichot,Antonio Zorzano,Antonio Zorzano,Roser Masgrau,Elena Galea,Elena Galea,Siddharthan Chandran,Siddharthan Chandran,David J. A. Wyllie,T. Ian Simpson,Giles E. Hardingham +23 more
TL;DR: A system combining cortical neurons and astrocytes from closely related species, followed by RNA-seq and in silico species separation, uncovers a wide programme of neuron-inducedAstrocytic gene expression, involving Notch signalling, which drives and maintains astroCytic maturity and neurotransmitter uptake function, is conserved in human development, and is disrupted by neurodegeneration.
Expression of mRNA Encoding Mcu and Other Mitochondrial Calcium Regulatory Genes Depends on Cell Type, Neuronal Subtype, and Ca2+ Signaling
Nóra M. Márkus,Philip Hasel,Jing Qiu,Karen F.S. Bell,Samuel Heron,Peter C. Kind,Peter C. Kind,Owen Dando,T. Ian Simpson,Giles E. Hardingham +9 more
TL;DR: The Mcu-regulating Micu gene family profile differs substantially between neurons and astrocytes, while expression of Mcu itself is markedly different between CA3 and CA1 regions in the adult hippocampus, and dynamic control of MCRG mRNA expression in response to membrane depolarization-induced Ca2+ influx is apparent.
Mixed-species RNA-seq for elucidation of non-cell-autonomous control of gene transcription.
Jing Qiu,Owen Dando,Paul Baxter,Philip Hasel,Samuel Heron,T. Ian Simpson,Giles E. Hardingham +6 more
TL;DR: This protocol describes the co-culture of cells from multiple species and, after RNA-seq, the separation of reads by species via the Sargasso bioinformatics pipeline to elucidate the effects of one cell type on the transcriptome of the others.
Integration of questionnaire-based risk factors improves polygenic risk scores for human coronary heart disease and type 2 diabetes
M. Tamlander,Nina Mars,Matti Pirinen,Aarno Mark Palotie Daly,Aarno Palotie,Mark J. Daly,Bridget Riley-Gills,Howard J. Jacob,Dirk Paul,Heiko Runz,Sally John,Robert M. Plenge,Joseph Maranville,George Okafo,Nathan Lawless,Heli Salminen-Mankonen,Mark A. McCarthy,Julie Hunkapiller,Meg Ehm,Kirsi Auro,Simonne Longerich,Caroline Marie Fox,Anders Mälarstig,K W Klinger,Deepak Raipal,Eric Green,Rob Graham,Robert. Yang,Christopher J. O'Donnell,Tomi P. Mäkelä,Jaakko Kaprio,Petri Virolainen,A Hakanen,Terhi Kilpi,Markus Perola,Jukka Partanen,Anne Pitkäranta,Raisa Serpi,Tarja Laitinen,Veli-Matti Kosma,Arto Mannermaa,M. Hautalahti,Outi Raimo Tuovila Pakkanen,Outi Tuovila,Raimo Pakkanen,Jeff Waring,Ioanna Tachmazidou,Chia-Yen Chen,Shameek Biswas,Zhihao Ding,Marc Rudolf Jung,R. Pendergrass,D. Lynn Pulford,Neha S. Raghavan,Adriana Huertas-Vazquez,Jaehoon Sul,Xinli Hu,Sahar V. Mozaffari,Dawn M. Waterworth,Nicole A. Renaud,Ma'en Obeidat,Samuli Ripatti,Olli Carpén,Reetta Hinttala,Katriina Aalto-Setälä,Johanna Mäkelä,Reetta Kälviäinen,Valtteri Julkunen,Hilkka Soininen,Anne M. Remes,Mikko Hiltunen,Jukka Peltola,Pentti J. Tienari,Juha Rinne,Roosa E. Kallionpää,Ali Rafsanjani Abbasi,Adam Ziemann,S. Esmaeeli,Nizar Smaoui,A. Lehtonen,Susan L. Eaton,S. Lahdenperä,Janet van Adelsberg,Natalie Bowers,Edmond Teng,S. Pendergrass,Onuralp Soylemez,Karin Palm Linden,Fanli Xu,Laura Addis,John D. Eicher,Minna M. Raivio,Beryl B. Cummings,Juulia Partanen,Martti Färkkilä,Jukka Koskela,Sampsa Pikkarainen,Airi Jussila,Katri Kaukinen,Timo Blomster,Mikko Kiviniemi,M. Voutilainen,Graham A. Heap,Fedik Rahimov,Keith Usiskin,Tim Lu,D. Oh,Kirsi Kalpala,Melissa R. Miller,Linda McCarthy,Kari K. Eklund,Antti Palomäki,Pia Isomäki,Laura Pirilä,Oili Kaipiainen-Seppänen,Johanna A. Huhtakangas,Apinya Lertratanakul,David Close,Marla Hochfeld,Nan Bing,J. Gordillo,Margit K. Pelkonen,Paula Kauppi,Hannu Kankaanranta,Terttu Harju,Riitta Lahesmaa,A. Mackay,Glenda Lassi,Steven Greenberg,Hubert Chen,J. Betts,Soumitra Ghosh,Rajashree Mishra,Sina Rüeger,Teemu J. Niiranen,Felix Vaura,Veikko Salomaa,Markus Juonala,Kaj Metsärinne,Mika Kähönen,M. Juhani Junttila,Markku Laakso,Jussi Pihlajamäki,Daniel Gordin,Juha Sinisalo,Marja-Riitta Taskinen,Tiinamaija Tuomi,Jari A. Laukkanen,Ben Challis,Jaakko Parkkinen,Russell Miller,Audrey Chu,Amanda F. Elliott,Joel T. Rämö,Mary Pat Reeve,Sanni Ruotsalainen,Tuomo J. Meretoja,Heikki Joensuu,Lauri A. Aaltonen,Johanna Mattson,Annika Auranen,Peeter Karihtala,Saila Kauppila,Päivi Auvinen,Klaus Elenius,Johanna Schleutker,Relja Popovic,Bridget Riley-Gillis,Jennifer L. Schutzman,Andrey Loboda,Aparna Chhibber,Heli J. Lehtonen,S. McDonough,Marika Crohns,Sauli Vuoti,Diptee Kulkarni,Esa Pitkänen,Kai Kaarniranta,Joni A. Turunen,Terhi Ollila,Sanna Seitsonen,Hannu Uusitalo,Vesa Aaltonen,Hannele Uusitalo-Järvinen,Marja Luodonpää,Nina Hautala,Mengzhen Liu,Stephanie Loomis,Erich Strauss,Hao Chen,Anna I. Podgornaia,Juha Karjalainen,Kaisa Tasanen,Laura Huilaja,Katariina Hannula-Jouppi,Teea Salmi,Sirkku Peltonen,Leena Koulu,Ying Wu,David Choy,Pirkko J. Pussinen,Aino Salminen,Tuula T. Salo,Dave Rice,Pekka Nieminen,Ulla Palotie,Maria Siponen,Liisa Suominen,Päivi Mäntylä,Ulvi Gursoy,Vuokko Anttonen,Kirsi Sipilä,Hannele Laivuori,Venla Kurra,Oskari Heikinheimo,Ilkka Kalliala,Laura Kotaniemi-Talonen,K. Nieminen,Päivi Polo,Kaarin Mäkikallio,Eeva Ekholm,Marja Vääräsmäki,Outi Uimari,Laure Morin-Papunen,Marjo Tuppurainen,Katja Kivinen,Elisabeth Widen,Taru Tukiainen,Liu Aoxing,Eija K. Laakkonen,Niko Välimäki,Johannes Kettunen,Mikko Arvas,J. Kumar,Andrea Ganna,Justin W. Davis,Danjuma Quarless,Slavé Petrovski,Eleonor Wigmore,Adele A. Mitchell,Benjamin Sun,Ellen A. Tsai,Denis Baird,Paola G. Bronson,Ruoyu Tian,Yunfeng Huang,Elmutaz Shaikho Elhaj Mohammed,Samir Wadhawan,Erika Kvikstad,Minal Çalışkan,Diana Solhee Chang,Tushar Bhangale,Kirill Shkura,Victor Neduva,Xing Chen,Åsa K. Hedman,Karen S. King,Padhraig Gormley,Jimmy Z. Liu,Clarence Wang,Ethan Y Xu,Franck Augé,Clément Chatelain,Deepak K. Rajpal,Dongyu Liu,Kathy Call,Tai-he Xia,Matthias Brauer,Huilei Xu,Amy L. Cole,Jonathan H. Chung,Jaison Jacob,Katrina M. de Lange,Jonas Zierer,Mitja I. Kurki,Aki S. Havulinna,Juha Mehtonen,Priit Palta,Shabbeer Hassan,P. della Briotta Parolo,Wei Zhou,Mutaamba Maasha,Susanna Lemmelä,M. Rivas,A. Lehisto,Vincent Llorens,Mari Niemi,Henrike O. Heyne,Kimmo Palin,Javier Garcia-Tabuenca,Harri Siirtola,Tuomo Kiiskinen,Jiwoo Lee,Kristin Tsuo,Kati Kristiansson,Kati Hyvärinen,Jarmo Ritari,Miika Koskinen,Katri Pylkäs,Marita Kalaoja,Minna M. Karjalainen,Tuomo Mantere,Eeva Kangasniemi,Sami Heikkinen,Samuel Heron,Dhanaprakash Jambulingam,Venkat Subramaniam Rathinakannan,Niina Pitkänen,Perttu Sirpa Eero Sanna Teijo Terho Soini Punkka Siltanen Kuopio,Perttu Terho,Sirpa Soini,E. Punkka,Susanna Siltanen,Teijo Kuopio,Anu Huei-Yi Risto Mervi Jalanko Shen Kajanne Aavikko,Anu Jalanko,Huei-Yi Shen,Risto Kajanne,Mervi Aavikko,Masahiro Kanai,Laura Lahtela,Mari A. Kaunisto,Elina Timo P. Oluwaseun Alexander Awaisa Anastasia Kilpeläinen Sipilä Dada Ghazal Kytölä,Elina Kilpeläinen,Timo Sipilä,Oluwaseun Alexander Dada,Awaisa Ghazal,Anastasia Kytölä,Kati Timo P. Donner Sipilä,Kati Donner,Anu Loukola,Päivi Laiho,T. Sistonen,Essi Kaiharju,Markku Laukkanen,Elina Järvensivu,Sini Lähteenmäki,Lotta Männikkö,R.-G. Wong,Minna Sami Tero Teemu Brunfeldt Koskelainen Hiekkalinna Paajanen,Minna Brunfeldt,Sami Koskelainen,Tero Hiekkalinna,Teemu Paajanen,Kalle Shuang Vishal Pärn Luo Sinha,Kalle Pärn,Shuang Luo,Vishal Sinha,Javier Gracia-Tabuenca,Mika Helminen,Tiina Luukkaala,Iida Vähätalo,J. Pitkänen,Mirkka Sarah Tom Koivusalo Smith Southerington,Mirkka Koivusalo,Sarah Smith,Tom Southerington +356 more
TL;DR: In this article , the authors describe the derivation and validation of genomics-enhanced risk tools for two common cardiometabolic diseases, coronary heart disease and type 2 diabetes.
Author Correction: Neurons and neuronal activity control gene expression in astrocytes to regulate their development and metabolism
Philip Hasel,Owen Dando,Zoeb Jiwaji,Paul D. Baxter,Alison C Todd,Samuel Heron,Nóra M. Márkus,Jamie McQueen,David W. Hampton,Megan Torvell,Sachin S. Tiwari,Sean McKay,Abel Eraso-Pichot,Antonio Zorzano,Roser Masgrau,Elena Galea,Siddharthan Chandran,David J. A. Wyllie,T. Ian Simpson,Giles E. Hardingham +19 more
TL;DR: In this article, Goedert, who developed the Thy1-P301S transgenic mouse, was inadvertently omitted from the Acknowledgments section of this article, which should have included the following: ‘We thank Michel GOEDERT for providing the Thy 1-P 301S transgeny that was used in this study.