Samuel Flashner
Drexel University
27 Papers
Samuel Flashner is an academic researcher from Drexel University. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 2, co-authored 3 publications.
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Papers
Detergent exposure induces epithelial barrier dysfunction and eosinophilic inflammation in the esophagus
Alfred D. Doyle,Mia Masuda,Grace Pyon,Huijun Luo,Arina Putikova,William E. LeSuer,Samuel Flashner,Matthew A. Rank,Hiroshi Nakagawa,Hirohito Kita,Benjamin L. Wright +10 more
TL;DR: Exposure to SDS decreases esophageal barrier integrity, stimulates IL-33 production, and promotes epithelial hyperplasia and tissue eosinophilia, which may be a key environmental trigger in EoE pathogenesis.
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Tumor suppressor mediated ubiquitylation of hnRNPK is a barrier to oncogenic translation
Bartosz Mucha,Shuo Qie,Sagar Bajpai,Vincenzo Tarallo,J. Nathaniel Diehl,Frank A. Tedeschi,Gao Zhou,Zhaofeng Gao,Samuel Flashner,Andres J. Klein-Szanto,Hanina Hibshoosh,Shimonosono Masataka,Olga S. Chajewski,Ireneusz Majsterek,Dariusz Pytel,Maria Hatzoglou,Channing J. Der,Hiroshi Nakagawa,Adam J. Bass,Kwok-Kin Wong,Serge Y. Fuchs,Anil K. Rustgi,Eckhard Jankowsky,J. Alan Diehl +23 more
TL;DR: In this paper , the SCFFbxo4 E3 ubiquitin ligase restricts the pro-oncogenic activity of hnRNPK via K63 linked polyubiquitylation, thus limiting its ability to bind target mRNA.
Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids.
Samuel Flashner,Cecilia Martin,Norihiro Matsuura,Masataka Shimonosono,Yasuto Tomita,Masaki Morimoto,Ogoegbunam Okolo,Victoria X Yu,Anuraag S. Parikh,Andres J. Klein-Szanto,Kelley Yan,Joel Gabre,Chao Lu,Fatemeh Momen-Heravi,Anil K. Rustgi,Hiroshi Nakagawa +15 more
TL;DR: In this article , the authors demonstrate how to generate 3D organoids from normal, preneoplastic, and SCC murine esophageal tissue and maintain and cryopreserve these organoids.
8
Protocol for tumor dissociation and fluorescence-activated cell sorting of human head and neck cancers
Ogoegbunam Okolo,Victoria E. Yu,Samuel Flashner,Cecilia Martin,Hiroshi Nakagawa,Derrick T. Lin,Sidharth V. Puram,Anuraag S. Parikh +7 more
TL;DR: A step-by-step approach for the dissociation of fresh human head and neck tumor specimens, followed by isolation of viable single cells using fluorescence-activated cell sorting is described in this paper .
2
Transcription factor Sp1 regulates mitotic chromosome assembly and segregation
TL;DR: In this article , the ubiquitously expressed transcription factor specificity protein 1 (Sp1) has been shown to play a mitosis-specific role in chromosome segregation during mitosis.