Samuel Edwin
National Institutes of Health
55 Papers
712 Citations
Samuel Edwin is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Pregnancy & Preeclampsia. The author has an hindex of 31, co-authored 55 publications.
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Papers
A Prospective Cohort Study of the Value of Maternal Plasma Concentrations of Angiogenic and Anti-angiogenic Factors in Early Pregnancy and Midtrimester in the Identification of Patients Destined to Develop Preeclampsia
Juan Pedro Kusanovic,Roberto Romero,Tinnakorn Chaiworapongsa,Offer Erez,Pooja Mittal,Edi Vaisbuch,Shali Mazaki-Tovi,Francesca Gotsch,Samuel Edwin,Ricardo Gomez,Lami Yeo,Agustin Conde-Agudelo,Sonia S. Hassan +12 more
TL;DR: The PlGF/sEng ratio and its delta and slope had an excellent predictive performance for the prediction of early-onset preeclampsia, with very high likelihood ratio for a positive test result and very low likelihood ratios for a negative test result.
Antimicrobial peptides in amniotic fluid: defensins, calprotectin and bacterial/permeability-increasing protein in patients with microbial invasion of the amniotic cavity, intra-amniotic inflammation, preterm labor and premature rupture of membranes.
Jimmy Espinoza,Tinnakorn Chaiworapongsa,R. Romero,Samuel Edwin,C. Rathnasabapathy,R. Gomez,Emmanuel Bujold,Natalia Camacho,Yeon Mee Kim,Sonia S. Hassan,Sean C. Blackwell,Janice E. Whitty,Susan Berman,Mark Redman,B. H. Yoon,Yoram Sorokin +15 more
TL;DR: Elevated amniotic fluid concentrations of BPI, immunoreactive HNP 1-3, BPI and calprotectin are associated with intra-amniotic inflammation, histological chorioamnionitis and shorter amniocentesis-to-delivery interval in patients presenting with preterm labor with intact membranes.
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First-trimester maternal serum PP13 in the risk assessment for preeclampsia
Roberto Romero,Roberto Romero,Juan Pedro Kusanovic,Juan Pedro Kusanovic,Nandor Gabor Than,Nandor Gabor Than,Offer Erez,Francesca Gotsch,Jimmy Espinoza,Jimmy Espinoza,Samuel Edwin,Ilana Chefetz,Ricardo Gomez,Jyh Kae Nien,Marei Sammar,Beth L. Pineles,Sonia S. Hassan,Sonia S. Hassan,Hamutal Meiri,Yossi Tal,Ido Kuhnreich,Zoltán Papp,Howard Cuckle,Howard Cuckle +23 more
TL;DR: Maternal serum first-trimester PP13 appears to be a reasonable marker for risk assessment for preterm preeclampsia but a weak marker for severe preeclampia at term, and ineffective for identifying mild preeclamping at term.
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Normal pregnancy is characterized by systemic activation of the complement system
Karina Richani,Eleazar Soto,Jimmy Espinoza,Jyh Kae Nien,Tinnakorn Chaiworapongsa,Samuel Edwin,Moshe Mazor,Roberto Romero +7 more
TL;DR: Normal human pregnancy is associated with evidence of complement activation, as determined by higher concentrations of the anaphylatoxins C3a, C4a and C5a in the maternal circulation, and it is proposed that physiologic activation of the complement system during pregnancy is a compensatory mechanism aimed at protecting the host against infection.
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The anti-inflammatory limb of the immune response in preterm labor, intra-amniotic infection/inflammation, and spontaneous parturition at term: A role for interleukin-10
Francesca Gotsch,Roberto Romero,Juan Pedro Kusanovic,Offer Erez,Jimmy Espinoza,Chong Jai Kim,Edi Vaisbuch,Nandor Gabor Than,Shali Mazaki-Tovi,Tinnakorn Chaiworapongsa,Moshe Mazor,Bo Hyun Yoon,Samuel Edwin,Ricardo Gomez,Pooja Mittal,Sonia S. Hassan,Surendra Sharma +16 more
TL;DR: It is proposed that IL-10 has a role in the regulation of the immune response in vivo by initiating actions that dampen inflammation.
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