Samuel E. Sherman
University of Pennsylvania
15 Papers
4 Citations
Samuel E. Sherman is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Chemistry & Vesicle. The author has an hindex of 12, co-authored 15 publications.
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Papers
Mimicking Complex Biological Membranes and Their Programmable Glycan Ligands with Dendrimersomes and Glycodendrimersomes
TL;DR: All aspects of the synthesis of Janus dendrimers and JGDs and their biological activity and applications after assembly in aqueous media are covered.
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Glycodendrimersomes from Sequence-Defined Janus Glycodendrimers Reveal High Activity and Sensor Capacity for the Agglutination by Natural Variants of Human Lectins
Shaodong Zhang,Qi Xiao,Samuel E. Sherman,Adam Muncan,Andrea D. M. Ramos Vicente,Zhichun Wang,Daniel A. Hammer,Dewight Williams,Yingchao Chen,Darrin J. Pochan,Sabine Vértesy,Sabine André,Michael L. Klein,Hans-Joachim Gabius,Virgil Percec +14 more
TL;DR: The applicability of Janus-GDs to dissect structure-activity relationships between programmable cell surface models and human lectins in a highly sensitive and physiologically relevant manner is illustrated.
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Exploring functional pairing between surface glycoconjugates and human galectins using programmable glycodendrimersomes.
Qi Xiao,Anna-Kristin Ludwig,Cecilia Romanò,Irene Buzzacchera,Irene Buzzacchera,Samuel E. Sherman,M. Vetro,Sabine Vértesy,Herbert Kaltner,Ellen H. Reed,Martin Möller,Christopher J. Wilson,Daniel A. Hammer,Stefan Oscarson,Michael L. Klein,Hans-Joachim Gabius,Virgil Percec +16 more
TL;DR: How synthetic JGD-headgroup tailoring teamed with protein engineering and network assays can help explain how molecular matchmaking operates in the cellular context of glycan and lectin complexity is demonstrated.
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Bioactive cell-like hybrids coassembled from (glyco)dendrimersomes with bacterial membranes
Qi Xiao,Srujana S. Yadavalli,Shaodong Zhang,Samuel E. Sherman,Elodie Fiorin,Louise da Silva,Daniela A. Wilson,Daniel A. Hammer,Sabine André,Hans-Joachim Gabius,Michael L. Klein,Mark Goulian,Virgil Percec +12 more
TL;DR: The present coassembly method is likely to create cell-like hybrids from any biological membrane including human cells and thus may enable practical application in nanomedicine.
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Bioactive cell-like hybrids from dendrimersomes with a human cell membrane and its components
Srujana S. Yadavalli,Srujana S. Yadavalli,Qi Xiao,Qi Xiao,Samuel E. Sherman,William D. Hasley,Michael L. Klein,Mark Goulian,Virgil Percec +8 more
TL;DR: The coassembly of human membrane vesicles with dendrimersomes stabilizes the delicate humancell membranes, introducing the potential for the study of human cell membranes and of their constituents in vitro in a more robust environment.
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