Samuel E. Champer
Cornell University
17 Papers
Samuel E. Champer is an academic researcher from Cornell University. The author has contributed to research in topics: Gene drive & Population. The author has an hindex of 9, co-authored 11 publications.
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Papers
Computational and experimental performance of CRISPR homing gene drive strategies with multiplexed gRNAs
Samuel E. Champer,Suh Yeon Oh,Chen Liu,Zhaoxin Wen,Andrew G. Clark,Philipp W. Messer,Jackson Champer +6 more
TL;DR: It is found that homing drives have an optimal number of gRNAs, usually between two and eight, depending on the specific drive type and performance parameters, contradict the notion that resistance rates can be reduced to arbitrarily low levels by gRNA multiplexing.
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Performance analysis of novel toxin-antidote CRISPR gene drive systems
TL;DR: This study conducts a comprehensive performance assessment of several new types of CRISPR-based gene drive systems employing toxin-antidote (TA) principles, which should be less prone to resistance and allow for the confinement of drives to a target population due to invasion frequency thresholds.
Suppression gene drive in continuous space can result in unstable persistence of both drive and wild‐type alleles
TL;DR: In this paper, the authors show that the release of a suppression drive can result in what they term "chasing" dynamics, in which wild-type individuals recolonize areas where the drive has locally eliminated the population.
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Performance analysis of novel toxin-antidote CRISPR gene drive systems
TL;DR: The results suggest that CRISPR-based TA gene drives provide promising candidates for further development in a variety of organisms and may allow for flexible ecological engineering strategies.
Population Dynamics of Underdominance Gene Drive Systems in Continuous Space.
TL;DR: It is found that all proposed underdominance systems in continuous-space can fail to persist in such environments, even after an initially successful establishment in the release area, confirming previous theoretical results from diffusion theory and indicating that realistic spatial context must be considered when assessing strategies for the deployment of underDominance drives.
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