Samantha E. Spellicy
University of Georgia
14 Papers
6 Citations
Samantha E. Spellicy is an academic researcher from University of Georgia. The author has contributed to research in topics: Medicine & Extracellular vesicle. The author has an hindex of 5, co-authored 10 publications. Previous affiliations of Samantha E. Spellicy include Georgia Regents University & University System of Georgia.
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Papers
Human Neural Stem Cell Extracellular Vesicles Improve Recovery in a Porcine Model of Ischemic Stroke.
Robin L. Webb,Erin E. Kaiser,Brian J. Jurgielewicz,Samantha E. Spellicy,Shelley L. Scoville,Tyler A. Thompson,Raymond Swetenburg,David C. Hess,Franklin D. West,Steven L. Stice +9 more
TL;DR: This study demonstrated for the first time that in a large animal model novel NSC EV significantly improved neural tissue preservation and functional levels post-MCAO, suggesting NSC EVs may be a paradigm changing stroke therapeutic.
203
Minocycline in Acute Cerebral Hemorrhage: An Early Phase Randomized Trial
Abdelrahman Y. Fouda,Andrea Sikora Newsome,Samantha E. Spellicy,Jennifer L. Waller,Wenbo Zhi,David C. Hess,Adviye Ergul,David J. Edwards,Susan C. Fagan,Jeffrey A. Switzer +9 more
TL;DR: In intracerebral hemorrhage, a 400 mg dose of minocycline was safe and achieved neuroprotective serum concentrations, however, oral administration led to delayed absorption in these critically ill patients and should not be used when rapid, high concentrations are desired.
84
Extracellular Vesicles Mediate Neuroprotection and Functional Recovery after Traumatic Brain Injury
Min Kyoung Sun,Austin P. Passaro,Charles-Francois Vincent Latchoumane,Samantha E. Spellicy,Michael Bowler,Morgan Goeden,William J. Martin,Philip V. Holmes,Steven L. Stice,Lohitash Karumbaiah +9 more
TL;DR: This study demonstrates the neuroprotective and functional benefits of NSC EVs for treating TBI and points to gender-dependent effects on treatment outcomes, which requires further investigation.
58
Neural Stem Cell Extracellular Vesicles Disrupt Midline Shift Predictive Outcomes in Porcine Ischemic Stroke Model.
Samantha E. Spellicy,Erin E. Kaiser,Michael Bowler,Brian J. Jurgielewicz,Robin L. Webb,Franklin D. West,Steven L. Stice +6 more
TL;DR: It is suggested that MLS may be an important non-invasive biomarker that can be used to predict patient outcomes and prognosis as well as guide therapeutic intervention and rehabilitation in non-treated animals and potentially human patients that do not receive interventional treatments.
Exploring the predictive value of lesion topology on motor function outcomes in a porcine ischemic stroke model.
Kelly M. Scheulin,Brian J. Jurgielewicz,Samantha E. Spellicy,Elizabeth S. Waters,Emily W Baker,Holly A. Kinder,Gregory Simchick,Sydney E Sneed,Janet A. Grimes,Qun Zhao,Steven L. Stice,Franklin D. West +11 more
TL;DR: In this article, the authors identify key structures lesioned by a middle cerebral artery occlusion (MCAO) that impact stroke recovery and to strengthen the predictive capacity of neuroimaging techniques that characterize stroke outcomes in a translational porcine model.