Sam Willcocks
University of London
32 Papers
86 Citations
Sam Willcocks is an academic researcher from University of London. The author has contributed to research in topics: Biology & Gene. The author has an hindex of 10, co-authored 26 publications. Previous affiliations of Sam Willcocks include Royal Veterinary College.
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Papers
Antimicrobial resistance and COVID-19: Intersections and implications.
Gwenan M. Knight,Rebecca E Glover,C. Finn McQuaid,Ioana D. Olaru,Karin Gallandat,Quentin J Leclerc,Naomi M. Fuller,Sam Willcocks,Rumina Hasan,Rumina Hasan,Esther van Kleef,Clare I R Chandler +11 more
TL;DR: In this article, changes due to the coronavirus 2019 pandemic in terms of antimicrobial usage, infection prevention, and health systems affect the emergence, transmission, and burden of AMR.
The importance of the glycosylation of antimicrobial peptides: natural and synthetic approaches.
TL;DR: The current availability of synthetic coupling and glycoengineering technology makes it possible to customise the most beneficial glycan modifications for improved AMP stability, microbicidal potency, pathogen specificity, tissue or cell targeting, and immunomodulation.
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Intracellular replication of the well-armed pathogen Burkholderia pseudomallei.
TL;DR: Recent advances in understanding of the intracellular survival of Burkholderia pseudomallei are highlighted, including how it overcomes host immune defenses and other challenges to establish its niche and then spread the infection.
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Species-specific PAMP recognition by TLR2 and evidence for species-restricted interaction with Dectin-1
TL;DR: The results indicate that the strength of the response to any TLR2 ligand tested was dependent on the extracellular, solenoid structure, but not the intracellular TIR domain, and that collaborative recognition of distinct microbial components by different classes of innate‐immune receptors is crucial in orchestrating inflammatory responses.
43
Trehalose dimycolate interferes with FcγR-mediated phagosome maturation through Mincle, SHP-1 and FcγRIIB signalling.
Emmanuel C. Patin,Anna C. Geffken,Sam Willcocks,Christoph Leschczyk,Albert Haas,Falk Nimmerjahn,Roland Lang,Theresa H. Ward,Ulrich E. Schaible +8 more
TL;DR: It is shown that recruitment of Mincle by TDM coupled to immunoglobulin (Ig)G-opsonised beads during Fcγ receptor (FcγR)-mediated phagocytosis interferes with phagosome maturation, and important mechanisms contributing to the virulence of TDM are revealed.