Salvatore Cisternino
University of Paris
125 Papers
387 Citations
Salvatore Cisternino is an academic researcher from University of Paris. The author has contributed to research in topics: Medicine & Blood–brain barrier. The author has an hindex of 28, co-authored 106 publications. Previous affiliations of Salvatore Cisternino include IBM & Peter MacCallum Cancer Centre.
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Papers
Pharmacophore-Based Discovery of Substrates of a Novel Drug/Proton-Antiporter in the Human Brain Endothelial hCMEC/D3 Cell Line
Maria Smirnova,Laura Goracci,Gabriele Cruciani,Laetitia Federici,Xavier Declèves,Hélène Chapy,Salvatore Cisternino +6 more
TL;DR: This model marks a new step in the characterization of this drug/proton-antiporter and will be of great use in uncovering its substrates and designing chemical entities with an improved influx capability to cross the BBB.
Stability and Formulation of Erlotinib in Skin Creams
David Nguyen,Philippe-Henri Secrétan,C. Cotteret,Emmanuelle Jacques-Gustave,Céline Greco,Christine Bodemer,Joël Schlatter,Salvatore Cisternino +7 more
TL;DR: In this article , a method to prepare 0.2% ERL cream, without resorting to a pure active pharmaceutical ingredient, was developed and the formulation was optimized to improve ERL stability over time.
Respiratory toxicity of buprenorphine results from the blockage of P-glycoprotein-mediated efflux of norbuprenorphine at the blood-brain barrier in mice.
Hisham Alhaddad,Salvatore Cisternino,Xavier Declèves,Nicolas Tournier,Joël Schlatter,Fouad Chiadmi,Patricia Risède,Maria Smirnova,Capucine Besengez,Jean-Michel Scherrmann,Frédéric J. Baud,Bruno Mégarbane +11 more
TL;DR: A major role for drug–drug interactions that lead to P-glycoprotein inhibition in buprenorphine-associated fatalities and respiratory depression is suggested, suggesting a key-protective role in norbuprenorphines transport at the blood–brain barrier.
Effect of Subchronic Intravenous Morphine Infusion and Naloxone‐Precipitated Morphine Withdrawal on P‐gp and Bcrp at the Rat Blood–Brain Barrier
Catarina Chaves,David Gomez-Zepeda,David Gomez-Zepeda,David Gomez-Zepeda,Sylvain Auvity,Sylvain Auvity,Sylvain Auvity,Marie-Claude Menet,Marie-Claude Menet,Marie-Claude Menet,Dominique Crété,Dominique Crété,Dominique Crété,Laurence Labat,Fernando Remião,Salvatore Cisternino,Xavier Declèves +16 more
TL;DR: The study concludes subchronic continuous morphine infusion and naloxone-precipitated morphine withdrawal have poor effect on P-gp/Bcrp levels at the rat BBB.
Isolation and differential transcriptome of vascular smooth muscle cells and mid-capillary pericytes from the rat brain
Stéphanie Chasseigneaux,Stéphanie Chasseigneaux,Stéphanie Chasseigneaux,Yasmine Moraca,Yasmine Moraca,Yasmine Moraca,Véronique Cochois-Guégan,Véronique Cochois-Guégan,Véronique Cochois-Guégan,Anne-Cécile Boulay,Anne-Cécile Boulay,Anne-Cécile Boulay,Alice Gilbert,Alice Gilbert,Alice Gilbert,Stéphane Le Crom,Stéphane Le Crom,Corinne Blugeon,Cyril Firmo,Salvatore Cisternino,Salvatore Cisternino,Salvatore Cisternino,Jean-Louis Laplanche,Jean-Louis Laplanche,Jean-Louis Laplanche,Emmanuel Curis,Xavier Declèves,Xavier Declèves,Xavier Declèves,Bruno Saubaméa +29 more
TL;DR: The results refine the current description of the role of VSMCs in parenchymal cortical arterioles at the molecular level and provide a unique platform to identify the molecular mechanisms underlying the specific functions of mcPCs in the brain vasculature.