Saikumar Karyala
Virginia Bioinformatics Institute
20 Papers
382 Citations
Saikumar Karyala is an academic researcher from Virginia Bioinformatics Institute. The author has contributed to research in topics: Aryl hydrocarbon receptor & Biology. The author has an hindex of 15, co-authored 20 publications. Previous affiliations of Saikumar Karyala include University of Cincinnati & University of Cincinnati Academic Health Center.
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Papers
Host adaptive immunity alters gut microbiota
TL;DR: The results suggest that adaptive immunity has a pervasive role in regulating gut microbiota’s composition and diversity and that Rag1−/− mice had a higher gain in microbiota richness and evenness with increase in age compared with wild-type mice, possibly due to the lack of pressure from the adaptive immune system.
Expression of genes in the TGF-β signaling pathway is significantly deregulated in smooth muscle cells from aorta of aryl hydrocarbon receptor knockout mice
Junhai Guo,Maureen A. Sartor,Saikumar Karyala,Mario Medvedovic,Simone Kann,Alvaro Puga,Patrick H. Ryan,Craig R. Tomlinson +7 more
TL;DR: The RNA expression profiles support a hypothesis that in the wild type, the AHR represses Tgfb gene expression and affects the gene expression of several TGF-beta-modulating and processing genes, and are consistent with a hypotheses that TCDD stimulates the T GF-beta2 signaling pathway in the absence of the A HR.
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Genomewide analysis of aryl hydrocarbon receptor binding targets reveals an extensive array of gene clusters that control morphogenetic and developmental programs.
Maureen A. Sartor,Michael Schnekenburger,Jennifer Marlowe,John F. Reichard,Ying Wang,Yunxia Fan,Ci Ma,Saikumar Karyala,Danielle Halbleib,Xiangdong Liu,Mario Medvedovic,Alvaro Puga +11 more
TL;DR: An integrative genomewide analysis of AHR gene targets in mouse hepatoma cells found the naive receptor in unstimulated cells bound to an extensive array of gene clusters with functions in regulation of gene expression, differentiation, and pattern specification, connecting multiple morphogenetic and developmental programs.
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Ligand-Independent Regulation of Transforming Growth Factor β1 Expression and Cell Cycle Progression by the Aryl Hydrocarbon Receptor
Xiaoqing Chang,Yunxia Fan,Saikumar Karyala,Sandy Schwemberger,Craig R. Tomlinson,Maureen A. Sartor,Alvaro Puga +6 more
TL;DR: In this paper, the aryl hydrocarbon receptor (AHR) was shown to possess interconnected intrinsic cellular functions, such as ECM formation, cell cycle control, and TGF-β1 regulation, that are independent of activation by either exogenous or endogenous ligands.
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Lead Toxicity to the Performance, Viability, And Community Composition of Activated Sludge Microorganisms
Li Yuan,Li Yuan,Li Yuan,Wei Zhi,Yangsheng Liu,Saikumar Karyala,Peter J. Vikesland,Xi Chen,Husen Zhang +8 more
TL;DR: This study provides for the first time a systematic investigation of the effect of extended exposure of Pb on the performance and microbiology of aerobic treatment processes, and it indicates that long-term Pb toxicity has been underappreciated by previous studies.
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