https://mail.phcogj.com/sites/default/files/10.5530pj.2017.5.107_1.pdf

Comprehensive Evaluation of Antioxidant Potential of Selected Osbeckia species and their in vitro Culture, Purification and Fractionation

Screening biological activities of orthosiphon aristatus: some observations.

Tylophora subramanii henry.an endemic medicinal herb - a source of potential antioxidant

Comparison of antioxidant potential of seaweeds: Kappaphycus alvarezii (doty) doty and hypnea musciformis (wulfen) j.v. lamouroux

Diabetes is a notorious and growing clinical and public health issue. The International Diabetes Federation assumes that 592 million had diabetes by 2035 and that by 2040 the number will increase to 642 million. Cardiovascular corollary accounts for four million deaths annually attributable to diabetes. Evidence reveals that certain glucose-lowering phytochemicals can improve vascular outcomes with type 2 diabetes, which, together with better understanding of using multiple therapies concurrently, offers opportunities for beneficial personalization of medication regimens. Anthocyanins are coloured pigments and are natural antioxidants. Keeping this in focus, this study was undertaken to evaluate the in vitro antidiabetic activity in the petals of wild Impatiens balsamina L. The anthocyanin was extracted from floral petals of wild balsam species and purified to homogeneity using chromatographic techniques. Evaluation of in vitro antidiabetic properties of anthocyanin extract revealed a dose-dependent increase in the inhibitory effect on the alpha-glucosidase (200 μg/ml) and alpha-amylase enzymes (500 μg/ml) and was comparable with the standard acarbose drug (189 μg/ml and 50 μg/ml). These results indicated that anthocyanin could be used as a source of functional food and nutraceuticals. This information from wild species will be useful in finding more potent antidiabetic principle from the natural resources for the clinical development of antidiabetic therapeutics. Future studies are planned to substantiate the antidiabetic power of anthocyanin using in vivo animal models.
Keywords: Alpha amylase, alpha glucosidase, diabetes, herbal remedies, Impatiens balsamina L.

/pdf/assessment-of-in-vitro-antidiabetic-potential-of-purified-44519pozr2.pdf

Assessment of In Vitro Antidiabetic Potential of Purified Anthocyanin Extract from Floral Petals of Wild Balsam Species

Free radicals/reactive oxygen species (ROSs)/reactive nitrogen species (RNSs) are produced by cells through endogenous reactions, various physiochemical events or pathological issues. Antioxidants (AOX) are compounds scavenge or regulate these radicals. The balance between these molecules and AOXs is a pre-requisite for healthy physiological functions of the body. If free radicals/ROS/ RNS over expresses in the system results into oxidative stress and other life style disorders i.e., oxidize lipids, proteins, nucleic acids and trigger a number of human diseases. Therefore, inclusion of antioxidants in food can assist in balancing this sort of oxidative bursts. Chemical antioxidants like butylated hydroxy anisole, butylated hydroxy toluene, propyl gallate and tert-butyl hydroquinone were employed in food resulted in to dangerous ill effects. Thus, the search for plant based biomolecules with antioxidative activity has been explored in recent times. The present overview provides an account of plants employed by the local people as antioxidants or functional foods or stress reliever in alleviating human diseases. The secondary metabolites analyzed in the present study as antioxidants include polyphenolics, carotenoids, alkaloids, terpenoids and flavonoids. These molecules function either as free radical scavengers or function by retarding chain initiation or involved in repair of damaged biomolecules. The output of the study will assist in providing knowledge regarding appropriate applications of the natural bioactive components in the regular diet as nutraceuticals.

https://www.ecronicon.com/ecpt/pdf/ECPT-08-00538.pdf

Secondary Metabolites and their Antioxidant Activities:An Overview

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Secondary Metabolites and their Antioxidant Activities:An Overview