18 Papers
Sai Yao is an academic researcher from Zhejiang Chinese Medical University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 3, co-authored 6 publications.
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Papers
Loganin ameliorates cartilage degeneration and osteoarthritis development in an osteoarthritis mouse model through inhibition of NF-κB activity and pyroptosis in chondrocytes
Jia-Ming Hu,Jin-Yi Zhou,Jin-Ting Wu,Quan Chen,Weibin Du,Fangda Fu,Huan Yu,Sai Yao,Hongting Jin,Peijian Tong,Di Chen,Chengliang Wu,Hongfeng Ruan +12 more
TL;DR: Results uncovered that loganin inhibits NF-κB signaling and attenuates cartilage matrix catabolism and pyroptosis of chondrocytes in articular cartilage and may serve as a potential therapeutic agent for OA treatment.
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Morroniside attenuates apoptosis and pyroptosis of chondrocytes and ameliorates osteoarthritic development by inhibiting NF-κB signaling.
Huan Yu,Sai Yao,Chengchong Zhou,Fangda Fu,Huan Luo,Weibin Du,Hongting Jin,Peijian Tong,Di Chen,Chengliang Wu,Hongfeng Ruan,Hongfeng Ruan +11 more
TL;DR: Morroniside was protective against cartilage matrix degradation and reduced DMM-induced chondrocyte pyroptosis and apoptosis by the inhibition of NF-κB signaling and attenuated the progression of OA in mice.
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Aberrant spinal mechanical loading stress triggers intervertebral disc degeneration by inducing pyroptosis and nerve ingrowth.
Fangda Fu,Ronghua Bao,Sai Yao,Chengcong Zhou,Huan Luo,Zhiguo Zhang,Huihao Zhang,Yan Li,Shuxin Yan,Huan Yu,Huan Yu,Weibin Du,Yanping Yang,Hongting Jin,Peijian Tong,Zhi-tao Sun,Ming Yue,Di Chen,Chengliang Wu,Hongfeng Ruan,Hongfeng Ruan +20 more
TL;DR: Mechanical instability caused by LSI surgery accelerates the disc matrix degradation, nerve invasion, pyroptosis, and eventually lead to IVDD, which provided an alternative mouse IVDD model.
Network Pharmacology and Experimental Validation to Reveal the Pharmacological Mechanisms of Liuwei Dihuang Decoction Against Intervertebral Disc Degeneration
Cadmium exposure promotes thyroid pyroptosis and endocrine dysfunction by inhibiting Nrf2/Keap1 signaling.
Yuying Chen,Chengcong Zhou,Y. Bian,Fangda Fu,Bian'an Zhu,Xuyan Zhao,Muxin Zhang,Chunyuan Zhou,Sai Yao,Zhiguo Zhang,Huan Luo,Yuying Ge,Chengliang Wu,Hongfeng Ruan +13 more
TL;DR: Wang et al. as mentioned in this paper showed that Cd exposure could reduce body weight and induce thyroid toxicity by impairing thyroid morphology and endocrine function, accompanied by elevated oxidative stress and apoptosis, macrophage infiltration, and inflammatory cytokine secretion.
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