Sai Ma
Harvard University
39 Papers
36 Citations
Sai Ma is an academic researcher from Harvard University. The author has contributed to research in topics: Chromatin & Biology. The author has an hindex of 16, co-authored 35 publications. Previous affiliations of Sai Ma include Broad Institute & Massachusetts Institute of Technology.
Chat about Author
Papers
Chromatin Potential Identified by Shared Single-Cell Profiling of RNA and Chromatin.
Sai Ma,Bing Zhang,Lindsay M. LaFave,Andrew S. Earl,Zachary Chiang,Yan Hu,Jiarui Ding,Alison Brack,Vinay K. Kartha,Tristan Tay,Travis Law,Caleb A. Lareau,Ya-Chieh Hsu,Aviv Regev,Aviv Regev,Aviv Regev,Jason D. Buenrostro,Jason D. Buenrostro +17 more
TL;DR: This work computationally infer chromatin potential as a quantitative measure of chromatin lineage-priming and use it to predict cell fate outcomes, and develops simultaneous high-throughput ATAC and RNA expression with sequencing (SHARE-seq), a highly scalable approach for measurement of Chromatin accessibility and gene expression in the same single cell.
824
Chromatin potential identified by shared single cell profiling of RNA and chromatin
Sai Ma,Sai Ma,Sai Ma,Bing Zhang,Lindsay M. LaFave,Lindsay M. LaFave,Zachary Chiang,Yan Hu,Jiarui Ding,Alison Brack,Vinay K. Kartha,Travis Law,Caleb A. Lareau,Caleb A. Lareau,Ya-Chieh Hsu,Aviv Regev,Aviv Regev,Aviv Regev,Jason D. Buenrostro,Jason D. Buenrostro +19 more
TL;DR: SHARE-seq is developed, a highly scalable approach for measurement of chromatin accessibility and gene expression within the same single cell, and a computational strategy to identify cis-regulatory interactions and define Domains of Regulatory Chromatin (DORCs), which significantly overlap with super-enhancers.
Deep learning and alignment of spatially resolved single-cell transcriptomes with Tangram.
Tommaso Biancalani,Gabriele Scalia,Gabriele Scalia,Lorenzo Buffoni,Raghav Avasthi,Raghav Avasthi,Ziqing Lu,Ziqing Lu,Aman Sanger,Neriman Tokcan,Charles R. Vanderburg,Asa Segerstolpe,Meng Zhang,Meng Zhang,Inbal Avraham-Davidi,Sanja Vickovic,Mor Nitzan,Mor Nitzan,Mor Nitzan,Sai Ma,Sai Ma,Sai Ma,Ayshwarya Subramanian,Michal Lipinski,Michal Lipinski,Jason D. Buenrostro,Jason D. Buenrostro,Nik Bear Brown,Duccio Fanelli,Xiaowei Zhuang,Xiaowei Zhuang,Evan Z. Macosko,Aviv Regev +32 more
TL;DR: Tangram as mentioned in this paper aligns single-cell and single-nucleus RNA-seq data to various forms of spatial data collected from the same region, including MERFISH, STARmap, smFISH and histological images.
Hyperactivation of sympathetic nerves drives depletion of melanocyte stem cells
Bing Zhang,Sai Ma,Sai Ma,Sai Ma,Inbal Rachmin,Megan He,Pankaj Baral,Sekyu Choi,William Antonio Gonçalves,Yulia Shwartz,Eva M. Fast,Yiqun Su,Leonard I. Zon,Leonard I. Zon,Aviv Regev,Aviv Regev,Aviv Regev,Jason D. Buenrostro,Thiago M. Cunha,Thiago M. Cunha,Isaac M. Chiu,David E. Fisher,Ya-Chieh Hsu +22 more
TL;DR: It is reported that, in mice, acute stress leads to hair greying through the fast depletion of melanocyte stem cells, and neuronal activity that is induced by acute stress can drive a rapid and permanent loss of somatic stem cells.
Transcriptional Atlas of Intestinal Immune Cells Reveals that Neuropeptide α-CGRP Modulates Group 2 Innate Lymphoid Cell Responses
Xu Heping,Xu Heping,Jiarui Ding,Caroline B. M. Porter,Antonia Wallrapp,Marcin Tabaka,Sai Ma,Shujie Fu,Xuanxuan Guo,Samantha J. Riesenfeld,Chien-wen Su,Danielle Dionne,Lan T. Nguyen,Ariel Lefkovith,Orr Ashenberg,Patrick R. Burkett,Hai Ning Shi,Orit Rozenblatt-Rosen,Daniel B. Graham,Vijay K. Kuchroo,Vijay K. Kuchroo,Aviv Regev,Aviv Regev,Ramnik J. Xavier +23 more
TL;DR: This work highlights a model where α-CGRP-mediated neuronal signaling is critical for suppressing ILC2 expansion and maintaining homeostasis of the type 2 immune machinery.
208