Terminalia chebula - review on pharmacological and biochemical studies.

Cryogels obtained by the cryotropic gelation process are macroporous hydrogels with a well-developed system of interconnected pores and shape memory. There have been significant recent advancements in our understanding of the cryotropic gelation process, and in the relationship between components, their structure and the application of the cryogels obtained. As cryogels are one of the most promising hydrogel-based biomaterials, and this field has been advancing rapidly, this review focuses on the design of biodegradable cryogels as advanced biomaterials for drug delivery and tissue engineering. The selection of a biodegradable polymer is key to the development of modern biomaterials that mimic the biological environment and the properties of artificial tissue, and are at the same time capable of being safely degraded/metabolized without any side effects. The range of biodegradable polymers utilized for cryogel formation is overviewed, including biopolymers, synthetic polymers, polymer blends, and composites. The paper discusses a cryotropic gelation method as a tool for synthesis of hydrogel materials with large, interconnected pores and mechanical, physical, chemical and biological properties, adapted for targeted biomedical applications. The effect of the composition, cross-linker, freezing conditions, and the nature of the polymer on the morphology, mechanical properties and biodegradation of cryogels is discussed. The biodegradation of cryogels and its dependence on their production and composition is overviewed. Selected representative biomedical applications demonstrate how cryogel-based materials have been used in drug delivery, tissue engineering, regenerative medicine, cancer research, and sensing.

Design and Assessment of Biodegradable Macroporous Cryogels as Advanced Tissue Engineering and Drug Carrying Materials

Novel polymeric hydrogel composites: Synthesis, physicochemical, mechanical and biocompatible properties

Sodium and acidic alginate foams with hierarchical porosity: Preparation, characterization and efficiency as a dye adsorbent

In the present study, acetone and methanol extract of T arjuna Roxb bark was evaluated for its phytochemical properties and antioxidant status by FRAP method The result indicated that tannin, alkaloid, triterpenoid, flavonoid, phytosteroids and saponin are present in both the acetone and methanol extract Total antioxidant status was found to be significantly (PE‚001) higher in acetone extract (2125Â±1155 ÂµM) as compared to methanol extract (3550Â±470 ÂµM) This indicates higher antioxidative property of T arjuna bark acetone extract in comparison to methanol extract and selected for in vivo study In vivo study, showed protective effect of acetone extract of T arjuna bark towards blood glucose, oral glucose tolerance (OGTT) and insulin tolarence test in STZ treated rats Feeding 500 mg/kg bw arjuna bark extract to rats showed significantly (P

https://www.phytojournal.com/archives/2013/vol2issue1/PartC/54.pdf

Phytochemical properties, total antioxidant status of acetone and methanol extract of Terminalia arjuna Roxb. bark and its hypoglycemic effect on Type-II diabetic albino rats.

The three-dimensional (3D) scaffold serves as a structural substrate and as a niche for cell proliferation to ensure tissue regeneration. Ideal scaffolds should have porous structures with high pore interconnectivity to allow cell adherence, differentiation, and proliferation while ensuring suitable mechanical strength and biodegradability without inflicting any immune response. Cross-linker is one of the major factors that affect the mechanical and biological properties of scaffolds. In this study, different chemical cross-linker effects on scaffold architecture were examined. Porous 3D scaffolds based on carrageenan and alginate (CA) were successfully fabricated by a freeze-drying technique and using various cross-linkers like glutaraldehyde (GA), genipin, and ethyl (dimethylamino propyl) carbodiimide/N-hydroxysuccinimide (EDC/NHS). The chemical cross-linker effects on the CA scaffold were characterized by scanning electron microscopy, differential scanning calorimetry, and thermogravimetry. A human fibroblast cell line (L929) was seeded into the fabricated scaffold, and cell proliferation was assessed by MTT and live/dead assay. Overall results suggested the potential cross-linkers for ideal CA biomaterial could be EDC/NHS among other agents tested as the scaffold CAEN was found to be porous, interconnected, and physically and mechanically stable. When compared to matrices with other cross-linkers, higher cell attachment, better cellular response, and higher metabolic activity could be observed in the scaffold synthesized using EDC/NHS as cross-linker.

Effect of cross-linkers in fabrication of carrageenan-alginate matrices for tissue engineering application.

In recent years, multiple drug resistance has been developed due to indiscriminate use of existing antimicrobial drugs in the treatment of infectious diseases. Conventional antibiotics are strong medicines, which if not used in precise way may cause harmful effects. The major thrust is to establish alternative antimicrobial agent in order to treat microbial infections with less or no toxic effect to body and less negligible side effects. The herbal medicines have shown potential to overcome the limitation associated with conventional drugs. However, the appropriate choice of source for herbal medicine is also very important. Terminalia chebula possesses potential pharmaceutical activities and used in several Ayurvedic formulations. The study of solvent-free organic (ethylacetate, acetone, methanol of increasing polarity) and aqueous extracts of the fruits of T. chebula, showed the potential to reduce growth of microorganisms, minimizing the risk of infection, while optimizing the conditions to encourage healing. In our study we found, methanol extract as a potential bactericidal and potent antioxidant while aqueous extract showed the least potential as an antimicrobial agent, though a moderate antioxidant. The finding may provide scientific rationale for the use of crude extract of the plant as a new drug compound as potential antioxidant and antimicrobial agent. Terminalia chebula is used as a mild laxative and as an astringent against wounds and abscesses. Practictioners of folk medicine in India and Southeast Asia use the fruit for homeostatic, laxative and as cardiotonic. It is used as a remedy against a sore throat and cough, against diarrhoea connected with a prolapsed rectum in China and against ulcers and dysentery in Tibet. The antibacterial activity of various extracts of Chebula myrobalan powder was tested against Streptococcus species, Staphylococcus aureus and Pseudomonas aeruginosa. II. MATERIALS T. chebula powder was purchased from local market of Mumbai, India. Pathogens of MTCC grade were obtained from IMTECH (Chandigarh, India). Gallic acid and Glutaraldehyde was purchased from s.d. fine-chemicals limited (Mumbai, India). Gentamicin and 2,4,6-tripyidyl-s-triazine (TPTZ) were procured from Hi-Media(Mumbai,India), 3-(4,5-dimethylthiazol-2-yl)-2,5- diphenyl tetrazolium bromide (MTT, 98%) reagent, 4'-6-diamidino-2-phenylindole (DAPI), propidium iodide (PI) and nystatin was purchased from Sigma (St. Louis, USA). Fetal bovine serum (FBS) and streptomycin-penicillin antibiotic solutions were bought from HyClone (Utah, USA). All other chemicals used were of analytical grade. SIRC (rabbit corneal epithelial cells) cell line was obtained from NCL, Pune, India

/pdf/therapeutical-effect-of-extracts-of-terminalia-chebula-in-c75pf7ovib.pdf

Therapeutical Effect of Extracts of Terminalia chebula In Inhibiting Human Pathogens and Free Radicals

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Effect of cross-linkers in fabrication of carrageenan-alginate matrices for tissue engineering application.

Therapeutical Effect of Extracts of Terminalia chebula In Inhibiting Human Pathogens and Free Radicals