12 Papers
Sae Tanaka is an academic researcher from National Institutes of Natural Sciences, Japan. The author has contributed to research in topics: Cryptobiosis & Desiccation tolerance. The author has an hindex of 3, co-authored 8 publications. Previous affiliations of Sae Tanaka include Keio University & University of Tokyo.
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Papers
Extremotolerant tardigrade genome and improved radiotolerance of human cultured cells by tardigrade-unique protein
Takuma Hashimoto,Daiki D. Horikawa,Daiki D. Horikawa,Daiki D. Horikawa,Yuki Saito,Hirokazu Kuwahara,Hirokazu Kuwahara,Hiroko Kozuka-Hata,Tadasu Shin-I,Yohei Minakuchi,Kazuko Ohishi,Ayuko Motoyama,Tomoyuki Aizu,Atsushi Enomoto,Koyuki Kondo,Sae Tanaka,Yuichiro Hara,Shigeyuki Koshikawa,Hiroshi Sagara,Toru Miura,Shin-ichi Yokobori,Kiyoshi Miyagawa,Yutaka Suzuki,Takeo Kubo,Masaaki Oyama,Yuji Kohara,Asao Fujiyama,Asao Fujiyama,Kazuharu Arakawa,Toshiaki Katayama,Atsushi Toyoda,Takekazu Kunieda +31 more
TL;DR: Using human cultured cells, it is demonstrated that a tardigrade-unique DNA-associating protein suppresses X-ray-induced DNA damage by ∼40% and improves radiotolerance, indicating the relevance of tardigrate-unique proteins to tolerability and tardigades could be a bountiful source of new protection genes and mechanisms.
Two Novel Heat-Soluble Protein Families Abundantly Expressed in an Anhydrobiotic Tardigrade
Ayami Yamaguchi,Sae Tanaka,Shiho Yamaguchi,Hirokazu Kuwahara,Chizuko Takamura,Shinobu Imajoh-Ohmi,Daiki D. Horikawa,Atsushi Toyoda,Toshiaki Katayama,Kazuharu Arakawa,Asao Fujiyama,Asao Fujiyama,Takeo Kubo,Takekazu Kunieda +13 more
TL;DR: A novel repertoire of major heat-soluble proteins in these anhydrobiotic animals is revealed and it is revealed that tardigrades might have evolved novel protein families with a heat- soluble property.
Novel Mitochondria-Targeted Heat-Soluble Proteins Identified in the Anhydrobiotic Tardigrade Improve Osmotic Tolerance of Human Cells
Sae Tanaka,Junko Tanaka,Yoshihiro Miwa,Daiki D. Horikawa,Toshiaki Katayama,Kazuharu Arakawa,Atsushi Toyoda,Takeo Kubo,Takekazu Kunieda +8 more
TL;DR: The findings of the present study revealed that tardigrade mitochondria contain at least two types of heat-soluble proteins that might have protective roles in water-deficient environments.
Desiccation-induced fibrous condensation of CAHS protein from an anhydrobiotic tardigrade.
Maho Yagi-Utsumi,Maho Yagi-Utsumi,Kazuhiro Aoki,Hiroki Watanabe,Chihong Song,Seiji Nishimura,Tadashi Satoh,Saeko Yanaka,Saeko Yanaka,Christian Ganser,Sae Tanaka,Sae Tanaka,Vincent Schnapka,Vincent Schnapka,Ean Wai Goh,Yuji Furutani,Yuji Furutani,Kazuyoshi Murata,Takayuki Uchihashi,Takayuki Uchihashi,Kazuharu Arakawa,Koichi Kato,Koichi Kato +22 more
TL;DR: In this article, the reversible self-assembling property of CAHS1 proteins was investigated in extremotolerant tardigrades, and it was found that CAHS proteins homo-oligomerized via the C-terminal α-helical region and formed a hydrogel as their concentration increased.
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A novel Mn-dependent peroxidase contributes to tardigrade anhydrobiosis
Yuki Yoshida,Tadashi Satoh,Chise Ota,Sae Tanaka,Daiki D. Horikawa,Masaru Tomita,Koichi Kato,Koichi Kato,Kazuharu Arakawa +8 more
TL;DR: Novel mechanisms for coping with oxidative stress that may be a fundamental mechanism of anhydrobiosis in tardigrades are demonstrated and localization of these sets of proteins in the Golgi apparatus suggests an indispensable role of the Gol Gi stress response in desiccation tolerance.
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