Saddek Mohand-Said
Vision Institute
155 Papers
1.1K Citations
Saddek Mohand-Said is an academic researcher from Vision Institute. The author has contributed to research in topics: Retinitis pigmentosa & Retinal. The author has an hindex of 38, co-authored 145 publications. Previous affiliations of Saddek Mohand-Said include Quinze-Vingts National Eye Hospital & Pierre-and-Marie-Curie University.
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Papers
Development and application of a next-generation-sequencing (NGS) approach to detect known and novel gene defects underlying retinal diseases
Isabelle Audo,Kinga M. Bujakowska,Kinga M. Bujakowska,Kinga M. Bujakowska,Thierry Léveillard,Thierry Léveillard,Thierry Léveillard,Saddek Mohand-Said,Marie-Elise Lancelot,Marie-Elise Lancelot,Marie-Elise Lancelot,Aurore Germain,Aurore Germain,Aurore Germain,Aline Antonio,Christelle Michiels,Christelle Michiels,Christelle Michiels,Jean-Paul Saraiva,Mélanie Letexier,José-Alain Sahel,Shomi S. Bhattacharya,Christina Zeitz,Christina Zeitz,Christina Zeitz +24 more
TL;DR: This unbiased and time-efficient NGS approach allowed mutation detection in 75% of control cases and in 57% of test cases and has the possibility of associating known gene defects with novel phenotypes and mode of inheritance.
Cystoid maculopathy is a frequent feature of Cohen syndrome-associated retinopathy.
Pierre-Henry Gabrielle,Laurence Faivre,Isabelle Audo,Isabelle Audo,Xavier Zanlonghi,Hélène Dollfus,Alberta A H J Thiadens,Christina Zeitz,Grazia M.S. Mancini,Yaumara Perdomo,Saddek Mohand-Said,Saddek Mohand-Said,Eléonore Lizé,Vincent Lhussiez,Emeline F. Nandrot,Niyazi Acar,Catherine Creuzot-Garcher,José-Alain Sahel,José-Alain Sahel,José-Alain Sahel,Muhammad Ansar,Christel Thauvin-Robinet,Laurence Duplomb,Romain Da Costa +23 more
TL;DR: In this article, a case series of 10 Cohen syndrome patients with identified pathogenic variants in VPS13B was used to improve the understanding and management of Cystoid maculopathy in CS patients through a retrospective case series.
Retinal Phenotype of Patients With Isolated Retinal Degeneration Due to CLN3 Pathogenic Variants in a French Retinitis Pigmentosa Cohort.
Vasily M Smirnov,Vasily M Smirnov,Marco Nassisi,Cyntia Solis Hernandez,Cécile Méjécase,Cécile Méjécase,Said El Shamieh,Said El Shamieh,Christel Condroyer,Aline Antonio,Isabelle Meunier,Camille Andrieu,Sabine Defoort-Dhellemmes,Saddek Mohand-Said,José-Alain Sahel,Isabelle Audo,Isabelle Audo,Isabelle Audo,Christina Zeitz +18 more
TL;DR: In this paper, a detailed description of the retinal phenotype of patients with isolated retinal degeneration harboring biallelic CLN3 pathogenic variants and to attempt a phenotype-genotype correlation associated with this gene defect was provided.
Test-Retest Variability of Functional and Structural Parameters in Patients with Stargardt Disease Participating in the SAR422459 Gene Therapy Trial.
Maria Parker,Dongseok Choi,Laura R Erker,Mark E. Pennesi,Paul Yang,Elvira N. Chegarnov,Peter N. Steinkamp,Catherine L. Schlechter,Claire Marie Dhaenens,Saddek Mohand-Said,Isabelle Audo,Jose A. Sahel,Richard G. Weleber,David J. Wilson +13 more
TL;DR: This analysis provides important information necessary to determine if significant changes are occurring in structural and functional assessments commonly used to measure disease progression in this cohort of patients with Stargardt Disease participating in the SAR422459 gene therapy clinical trial.
Transplantation of photoreceptor and total neural retina preserves cone function in P23H rhodopsin transgenic rat.
Ying Yang,Saddek Mohand-Said,Thierry Léveillard,Valérie Fontaine,Manuel Simonutti,José-Alain Sahel +5 more
TL;DR: It is demonstrated here that the transplanted tissue prevents the loss of cone function, which is further translated into cone survival.