Sabine Albold
Monash University
7 Papers
Sabine Albold is an academic researcher from Monash University. The author has contributed to research in topics: Allosteric regulation & Allosteric modulator. The author has an hindex of 7, co-authored 7 publications.
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Papers
β2-Adrenoceptors on tumor cells play a critical role in stress-enhanced metastasis in a mouse model of breast cancer.
Aeson Chang,Caroline P. Le,Adam K. Walker,Sarah J. Creed,Cindy K. Pon,Sabine Albold,Dominic Carroll,Michelle L. Halls,J. Robert Lane,Bernhard Riedel,Davide Ferrari,Erica K. Sloan,Erica K. Sloan,Erica K. Sloan +13 more
TL;DR: It is indicated that it may be necessary to block β2AR on tumor cells to fully control metastatic progression, and a crucial role forβ2AR tumor cell signaling in the adverse effects of stress on metastasis is highlighted.
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Structure-based discovery of selective positive allosteric modulators of antagonists for the M2 muscarinic acetylcholine receptor.
Magdalena Korczynska,Mary J. Clark,Celine Valant,Jun Xu,Ee Von Moo,Sabine Albold,Dahlia R. Weiss,Hayarpi Torosyan,Weijiao Huang,Andrew C. Kruse,Brent R. Lyda,Lauren T. May,Jo-Anne Baltos,Patrick M. Sexton,Brian K. Kobilka,Brian K. Kobilka,Arthur Christopoulos,Brian K. Shoichet,Roger K. Sunahara +18 more
TL;DR: The feasibility of discovering PAMs that can convert an armamentarium of potent but nonselective G-protein–coupled receptor (GPCR) antagonist drugs into subtype-selective reagents, thus reducing their off-target effects is supported.
"Selective" Class C G Protein-Coupled Receptor Modulators Are Neutral or Biased mGlu5 Allosteric Ligands.
Shane D. Hellyer,Sabine Albold,Taide Wang,Amy N. Y. Chen,Lauren T. May,Katie Leach,Karen J. Gregory +6 more
TL;DR: It is found that for many class C GPCR allosteric modulators, subtype selectivity is driven by cooperativity and misinterpreted owing to unappreciated bias.
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Structure-Based Design and Discovery of New M2 Receptor Agonists
Inbar Fish,Anne Stößel,Katrin Eitel,Celine Valant,Sabine Albold,Harald Huebner,Dorothee Möller,Mary J. Clark,Roger K. Sunahara,Arthur Christopoulos,Brian K. Shoichet,Peter Gmeiner +11 more
TL;DR: Using structure-guided pharmacophore design followed by docking, two agonists are found that fit the receptor well and were predicted to form a hydrogen-bond conserved among known agonists.
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Kinetic and system bias as drivers of metabotropic glutamate receptor 5 allosteric modulator pharmacology
Kathy Sengmany,Shane D. Hellyer,Sabine Albold,Taide Wang,P. Jeffrey Conn,Lauren T. May,Arthur Christopoulos,Katie Leach,Karen J. Gregory +8 more
TL;DR: The inherent complexity in mGlu5 NAM pharmacology is highlighted that may influence interpretation when translating into preclinical models and beyond in the design and development of novel therapeutics for neuropsychiatric and neurological disorders.
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