Saaya Saijo
Tohoku University
6 Papers
31 Citations
Saaya Saijo is an academic researcher from Tohoku University. The author has contributed to research in topics: Choroid & Self-healing hydrogels. The author has an hindex of 4, co-authored 6 publications.
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Papers
In situ formation of injectable chitosan-gelatin hydrogels through double crosslinking for sustained intraocular drug delivery
TL;DR: Results suggested that β-GD and genipin co-crosslinked chitosan-gelatin hydrogels could be a useful ocular drug delivery platform with enhanced therapeutic effects and reduced side effects.
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Pharmacokinetic and Safety Evaluation of a Transscleral Sustained Unoprostone Release Device in Monkey Eyes.
Nobuhiro Nagai,Shinji Yamada,Junichi Kawasaki,Eri Koyanagi,Saaya Saijo,Hirokazu Kaji,Matsuhiko Nishizawa,Toru Nakazawa,Toshiaki Abe +8 more
TL;DR: The device provided intraocular sustained delivery of UNO for 12 months without producing severe retinal toxicity and no changes were observed in retinal function as assessed by ERG, IOP, or macula thickness and retinal histology by OCT examinations during the 12-month period.
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A drug refillable device for transscleral sustained drug delivery to the retina
TL;DR: The refillable drug delivery device is a promising tool to administer drugs long‐term by reinjection with less invasiveness to intraocular tissues.
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Transscleral sustained ranibizumab delivery using an episcleral implantable device: Suppression of laser-induced choroidal neovascularization in rats.
Nobuhiro Nagai,Zhaleh Kashkouli Nezhad,Reiko Daigaku,Saaya Saijo,Yuanhui Song,Keiko Terata,Ayako Hoshi,Matsuhiko Nishizawa,Toru Nakazawa,Hirokazu Kaji,Toshiaki Abe +10 more
TL;DR: An episcleral implantable device for sustained release of ranibizumab is developed and its efficacy on suppression of laser-induced choroidal neovascularization (CNV) in rats is evaluated, indicating that prolonged sustained ranibzumab release could reduce the burden of repeated intravitreal injections.
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Controlled basic fibroblast growth factor release device made of poly(ethyleneglycol) dimethacrylates for creating a subcutaneous neovascular bed for cell transplantation.
Shinji Yamada,Nobuhiro Nagai,Saaya Saijo,Hirokazu Kaji,Matsuhiko Nishizawa,Imura Kozue,Masafumi Goto,Toshiaki Abe +7 more
TL;DR: A controlled bFGF releasing device could provide a neovascular bed with the required vascularization in the subcutaneous space and show a significant increase in the extent of vasculature that was dependent on the amount of bF GF loaded into the device.
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