S. Ziegler

TL;DR: Ziel/Aim Tau and 18 kDa translocator protein (TSPO) PET signals progress jointly during the continuum of neurodegenerative diseases, but it remains unclear if increasing TSPO PET signals dominantly reflect activated microglia or reactive astrocytes as discussed by the authors .

TL;DR: Ziel et al. as discussed by the authors investigated the effect of chronic pioglitazone treatment in a mouse model of tauopathy and found significant immunomodulation in amyloid-β (Aβ) dependent mouse models.

TL;DR: Ziel et al. as discussed by the authors performed a direct comparison of in vivo and in vitro glucose uptake by scRadiotracing and found that the energy metabolism of microglia highly motile in vivo is biased, when acting in vitro.

TL;DR: Ziel et al. as mentioned in this paper evaluated an image derived input function (IDIF) for an unbiased absolute quantification of [18F]PI-2620 tau-PET.