S. W. Schaffer
University of South Alabama
10 Papers
136 Citations
S. W. Schaffer is an academic researcher from University of South Alabama. The author has contributed to research in topics: Taurine & Calcium. The author has an hindex of 7, co-authored 10 publications.
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Papers
Role of osmoregulation in the actions of taurine.
TL;DR: The data reveal that certain actions of taurine are probably caused by the activation of osmotic-linked signaling pathways, and appear to be correlated with its membrane modulating and phosphorylation regulating activities.
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Interaction between the actions of taurine and angiotensin II.
TL;DR: In this article, the authors discuss three mechanisms that might underlie the beneficial effect of taurine in congestive heart failure, including its osmoregulatory activity in the kidney, its modulation of atrial natriuretic factor secretion and its putative regulation of vasopressin release.
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Mechanisms underlying taurine-mediated alterations in membrane function
TL;DR: None of these hypotheses can fully explain the membrane actions of taurine, which mediates a plethora of membrane-linked effects in excitable tissues.
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Shape and size changes induced by taurine depletion in neonatal cardiomyocytes
S. W. Schaffer,Cherry Ballard-Croft,Junichi Azuma,Kyoko Takahashi,D. G. Kakhniashvili,T. E. Jenkins +5 more
TL;DR: A role for taurine in the regulation of osmotic balance in the neonatal cardiomyocyte is supported, and some qualitative differences exist between cells osmotically stressed by increasing the osmolality of the incubation medium and decreasing intracellular oSMolality.
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Effect of ischemia, calcium depletion and repletion, acidosis and hypoxia on cellular taurine content.
TL;DR: It was found that large amounts of taurine also leave the cell during the calcium paradox, a condition induced by perfusing the heart with calcium containing buffer following a period of calcium free perfusion, but little taurin effluxes the hearts exposed to buffer whose pH was lowered to 6.6.
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