S Varga
Duke University
5 Papers
84 Citations
S Varga is an academic researcher from Duke University. The author has contributed to research in topics: Endoplasmic reticulum & ATPase. The author has an hindex of 5, co-authored 5 publications.
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Papers
Pressure effects on sarcoplasmic reticulum.
TL;DR: Protection against pressure inactivation was also observed in the presence of sucrose, glycerol, ethylene glycol and 1 M KCl, suggesting that water density modifying groups significantly affect the stability of Ca2+-ATPase under pressure.
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•Journal Article
Structure of Ca2+-ATPase in sarcoplasmic reticulum.
Anthony Martonosi,László Dux,Kenneth A. Taylor,H.P. Ting-Beall,S Varga,P. Csermely,N Mullner,Sandor Papp,Istvan Jona +8 more
TL;DR: In this paper, the morphology of sarcoplasmic reticulum, classification of Ca(2+)-ATPase (SERCA) isoenzymes presented in this membrane system, as well as their topology is reviewed.
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Similarity of three-dimensional microcrystals of detergent-solubilized (Na+,K+)-ATPase from pig kidney and Ca(2+)-ATPase from skeletal muscle sarcoplasmic reticulum.
Kenneth A. Taylor,S Varga +1 more
TL;DR: The three-dimensional structure of the alpha chain of the (Na+,K+)-ATPase is very similar to that of the Ca(2+)- ATPase despite their relatively weak overall sequence homology.
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Electron microscope observations on Ca2+-ATPase microcrystals in detergent-solubilized sarcoplasmic reticulum.
TL;DR: Cross-linking of Ca2+-ATPase crystals with glutaraldehyde protects the structure against conditions such as low Ca2+, high pH, elevated temperature, SH group reagents, high concentration of detergents, and removal of phospholipids by extraction with organic solvents that disrupt unfixed preparations.
[21] Analysis of two-dimensional crystals of Ca2+-ATPase in sarcoplasmic reticulum
TL;DR: This chapter focuses on the analysis of two-dimensional crystals of Ca 2+ -ATPase in sarcoplasmic reticulum, an intrinsic membrane protein with a molecular weight of 109,000 that alternates between two distinct conformations, E l and E 2 .