S Stein
University of Hamburg
10 Papers
1 Citations
S Stein is an academic researcher from University of Hamburg. The author has contributed to research in topics: CD8 & Cytokine. The author has an hindex of 3, co-authored 6 publications.
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Papers
Liver infiltrating T cells regulate bile acid metabolism in experimental cholangitis.
F Glaser,Clara John,Bastian Engel,B Höh,Sören Weidemann,Jan Dieckhoff,S Stein,Nathalie Becker,Christian Casar,Fenja Amrei Schuran,Björn Wieschendorf,M Preti,Friederike Jessen,Andre Franke,Antonella Carambia,Ansgar W. Lohse,Harald Ittrich,Johannes Herkel,Joerg Heeren,Christoph Schramm,Dorothee Schwinge +20 more
TL;DR: Dysregulation of bile acid metabolism as well as of T cells could contribute to the development of cholangiopathies and understanding the effect of lymphocytes on BA metabolism will help to design combined treatment strategies for cholestatic liver diseases.
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IL-17A/F enable cholangiocytes to restrict T cell-driven experimental cholangitis by upregulating PD-L1 expression.
S Stein,Lara Henze,Tobias Poch,Antonella Carambia,Till Krech,M Preti,Fenja Amrei Schuran,M Reich,Verena Keitel,Romina Fiorotto,Mario Strazzabosco,Lutz Fischer,Jun Li,Luisa Marie Müller,Jonas Wagner,Nicola Gagliani,Johannes Herkel,Dorothee Schwinge,Christoph Schramm +18 more
TL;DR: An important function of IL-17 is demonstrated in restricting cholangitis and protecting from CD8+ T cell mediated inflammatory bile duct injury that was mediated by upregulation of PD-L1 on Cholangiocytes.
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The effect of testosterone on human T cells in health and autoimmune liver disease
Lara Henze,S Stein,Jasper Meyer,Tobias Poch,Jenny Krause,Christian Casar,Johannes Fuß,Thomas Renné,Dorothee Schwinge,Christoph Schramm +9 more
- 01 Jan 2023
TL;DR: Females are more prone to develop autoimmune diseases, including primary biliary cholangitis (PBC), and the mechanisms underlying this dichotomy are still unknown as mentioned in this paper .
1
Increased in vivo and in vitro TH17 differentiation in patients with Primary Sclerosing Cholangitis
Lilly Kristin Kunzmann,Tanja Schoknecht,S Stein,Hanno Ehlken,Johannes Hartl,N Pannicke,Moritz Peiseler,Marcial Sebode,Christina Weiler-Normann,Roman Zenouzi,Ansgar W. Lohse,Johannes Herkel,Dorothee Schwinge,Christoph Schramm +13 more
1
IL-17A/F enable cholangiocytes to restrict T cell-driven experimental cholangitis via PD-1/PD-L1 interaction
S Stein,Lara Henze,Tobias Poch,Antonella Carambia,Till Krech,Max Preti,Fenja Amrei Schuran,M Reich,Verena Keitel,Romina Fiorotto,Mario Strazzabosco,Lutz Fischer,Jun Li,Luisa Müller,John E. Wagner,Nicola Gagliani,Johannes Herkel,Dorothee Schwinge,Christoph,Schramm +19 more
TL;DR: An important protective effect of IL-17 on cholangiocytes enabling them to downregulate bile duct inflammation via check point inhibitor PD-L1 is identified.