S. Segal
Saint Louis University
8 Papers
11 Citations
S. Segal is an academic researcher from Saint Louis University. The author has contributed to research in topics: Alzheimer's disease & Dentate nucleus. The author has an hindex of 6, co-authored 8 publications. Previous affiliations of S. Segal include New York University & Columbia University.
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Papers
Hippocampal and entorhinal atrophy in mild cognitive impairment Prediction of Alzheimer disease
Devangere P. Devanand,Gnanavalli Pradhaban,Xinhua Liu,Alexander G. Khandji,S. De Santi,S. Segal,Henry Rusinek,Gregory H. Pelton,Lawrence S. Honig,Richard Mayeux,Yaakov Stern,Matthias H. Tabert,M. J. de Leon +12 more
TL;DR: Smaller hippocampal and entorhinal cortex volumes each contribute to the prediction of conversion to Alzheimer disease, combining these MRI volumes with age and cognitive measures leads to high levels of predictive accuracy that may have potential clinical application.
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Longitudinal CSF and MRI biomarkers improve the diagnosis of mild cognitive impairment.
M. J. de Leon,M. J. de Leon,Susan DeSanti,Ray Zinkowski,Pankaj Mehta,Domenico Praticò,S. Segal,Henry Rusinek,Jialin Li,W. Tsui,W. Tsui,L. A. Saint Louis,Christopher M. Clark,Chaim Tarshish,Yi Li,L. Lair,Elizabeth Javier,Kenneth Rich,P. Lesbre,Lisa Mosconi,Barry Reisberg,Martin J. Sadowski,J.F. DeBernadis,Daniel J. Kerkman,Harald Hampel,Lars-Olof Wahlund,Peter Davies +26 more
TL;DR: Results demonstrate that CSF biomarkers for AD contribute to the characterization of MCI, and longitudinal hippocampal volume losses were closely associated with increasing hyperphosphorylated tau and decreasing amyloid beta-42 levels.
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MRI and CSF studies in the early diagnosis of Alzheimer's disease
M. J. de Leon,Susan DeSanti,Ray Zinkowski,Pankaj Mehta,Domenico Praticò,S. Segal,Christopher M. Clark,Daniel J. Kerkman,John F. DeBernardis,Jialin Li,L. Lair,Barry Reisberg,W. Tsui,W. Tsui,Henry Rusinek +14 more
TL;DR: In this article, the authors used MRI, FDG-PET, and CSF biomarkers to identify in cognitively normal elderly (NL) subjects and in patients with mild cognitive impairment (MCI), the earliest clinically detectable evidence for brain changes due to Alzheimer's disease (AD).
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The hippocampus and nucleus accumbens as potential therapeutic targets for neurosurgical intervention in schizophrenia.
Charles B. Mikell,Guy M. McKhann,S. Segal,Robert A. McGovern,Matthew B. Wallenstein,Holly Moore +5 more
TL;DR: It is hypothesize that inhibition or stabilization of neural activity with high-frequency electrical stimulation of the hippocampus or nucleus accumbens, through different mechanisms, would treat the positive symptoms of schizophrenia.
Longitudinal cerebrospinal fluid tau load increases in mild cognitive impairment.
M. J. de Leon,M. J. de Leon,S. Segal,Chaim Tarshish,Susan DeSanti,Ray Zinkowski,Pankaj Mehta,Antonio Convit,Antonio Convit,C. Caraos,Henry Rusinek,W. Tsui,W. Tsui,L. A. Saint Louis,John F. DeBernardis,Daniel J. Kerkman,F Qadri,A Gary,P. Lesbre,Thomas Wisniewski,John T. Poirier,Peter Davies +21 more
TL;DR: Longitudinally, only after adjusting for the ventricular volume and only for Ptau231, were increases seen in MCI, and further studies are warranted on mechanisms of tau clearance and on using imaging to interpret CSF studies.
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