S. Poggini
Istituto Superiore di Sanità
30 Papers
13 Citations
S. Poggini is an academic researcher from Istituto Superiore di Sanità. The author has contributed to research in topics: Fluoxetine & Antidepressant. The author has an hindex of 8, co-authored 23 publications. Previous affiliations of S. Poggini include Sapienza University of Rome.
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Papers
Fractalkine receptor deficiency impairs microglial and neuronal responsiveness to chronic stress
Giampaolo Milior,Cynthia Lecours,Louis Samson,Kanchan Bisht,S. Poggini,Francesca Pagani,Cristina Deflorio,Clotilde Lauro,Silvia Alboni,Cristina Limatola,Igor Branchi,Marie-Ève Tremblay,Laura Maggi +12 more
TL;DR: Hampering neuron-microglia communication via the CX3CR1-CX3CL1 pathway prevents the effects of chronic unpredictable stress on microglial function, short- and long-term neuronal plasticity and depressive-like behavior.
227
Interplay between inflammation and neural plasticity: Both immune activation and suppression impair LTP and BDNF expression
M.T. Golia,S. Poggini,Silvia Alboni,Stefano Garofalo,Naomi Ciano Albanese,A. Viglione,Maria Antonietta Ajmone-Cat,Abygaël St-Pierre,Nicoletta Brunello,Cristina Limatola,Igor Branchi,Laura Maggi +11 more
TL;DR: The present findings indicate that acute treatment with pro- and anti-inflammatory agents impair neural plasticity in a dose dependent manner.
112
Fluoxetine treatment affects the inflammatory response and microglial function according to the quality of the living environment.
Silvia Alboni,S. Poggini,Stefano Garofalo,Giampaolo Milior,Hassan El Hajj,Cynthia Lecours,Isabelle Girard,Steven Gagnon,Samuel Boisjoly-Villeneuve,Nicoletta Brunello,David P. Wolfer,Cristina Limatola,Marie-Ève Tremblay,Laura Maggi,Igor Branchi +14 more
TL;DR: Results show that the effects of fluoxetine treatment on inflammation and microglial function, as compared to vehicle, were dependent on the quality of the living environment and may be crucial to devise pharmacological strategies aimed at enhancing antidepressant efficacy by means of controlling environmental conditions.
99
Brain-immune crosstalk in the treatment of major depressive disorder
Igor Branchi,S. Poggini,Lucile Capuron,Francesco Benedetti,Sara Poletti,Ryad Tamouza,Hemmo A. Drexhage,Brenda W.J.H. Penninx,Carmine M. Pariante,Marion Leboyer +9 more
TL;DR: The link between the immune and the nervous system, which are deeply interconnected and continuously interacting, is one of the most important novel theoretical framework to investigate the biological bases of major depressive disorder and, more in general, mental illness as discussed by the authors.
53
Combined Fluoxetine and Metformin Treatment Potentiates Antidepressant Efficacy Increasing IGF2 Expression in the Dorsal Hippocampus.
S. Poggini,S. Poggini,M.T. Golia,Silvia Alboni,Giampaolo Milior,Giampaolo Milior,Livio Pepe’ Sciarria,A. Viglione,A. Viglione,Gloria Matte Bon,Nicoletta Brunello,Stefano Puglisi-Allegra,Cristina Limatola,Laura Maggi,Igor Branchi +14 more
TL;DR: The present results show that, when administered in stressful conditions, the combined fluoxetine and metformin treatment may represent a more effective approach than fluoxettine alone in a short term, and highlight the relevance of polypharmacological strategy as effective interventions to increase the efficacy of the antidepressant drugs currently available.