8 Papers
120 Citations
S Patel is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Cholesterol & Internal medicine. The author has an hindex of 6, co-authored 7 publications.
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Papers
Type C Niemann-Pick disease. Lysosomal accumulation and defective intracellular mobilization of low density lipoprotein cholesterol.
J Sokol,Joan Blanchette-Mackie,Howard S. Kruth,Nancy K. Dwyer,L M Amende,J D Butler,Elizabeth A. Robinson,S Patel,Roscoe O. Brady,M E Comly +9 more
TL;DR: Abnormal sequestration of LDL cholesterol in mutant cells within a metabolically latent pool is supported by the finding that in vitro esterification of cellular cholesterol could be stimulated in mutant but not in normal cell homogenates by extensive disruption of the intracellular membranous structures of cells previously cultured with LDL.
246
Progesterone blocks cholesterol translocation from lysosomes.
J D Butler,Joan Blanchette-Mackie,Ehud Goldin,Raymond R. O'Neill,G Carstea,Calvin F. Roff,Marc C. Patterson,S Patel,M E Comly,Adele Cooney +9 more
TL;DR: The progesterone-related inhibition and restoration of lysosomal cholesterol trafficking is a useful experimental means of studying intracellular cholesterol transport and a particularly important feature of its utility is the facile reversibility of the steroid-induced block.
178
Sterol-modulated Glycolipid Sorting Occurs in Niemann-Pick C1 Late Endosomes
Mei Zhang,Nancy K. Dwyer,Edward B. Neufeld,Dona C. Love,Adele Cooney,M E Comly,S Patel,Hidemichi Watari,Jerome F. Strauss,Peter G. Pentchev,John A. Hanover,E. Joan Blanchette-Mackie +11 more
TL;DR: It is concluded that the NPC1 compartment is a dynamic, sterol-modulated sorting organelle involved in the trafficking of plasma membrane-derived glycolipids as well as plasma membrane and endocytosed LDL cholesterol.
115
Gaucher's disease in a patient with chronic active hepatitis.
TL;DR: The clinical course of remissions and exacerbations of the disease activity was typical of "autoimmune" chronic active hepatitis and seemed unaffected by the coexistence of Gaucher's disease, and Steroid and immunosuppressive treatment resulted in prompt resolution of the chronic hepatitis.
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