Dopaminergic axons preferentially innervate dendritic spines with hyperactive glutamatergic synapses in the rat striatum.

Dopamine is a major neurotransmitter in the mammalian central nervous system (CNS) that regulates neuroendocrine functions, locomotor activity, cognition and emotion. The dopamine system has been extensively studied because dysfunction of this system is linked to various pathological conditions including Parkinson's disease, schizophrenia, Tourette's syndrome, and drug addiction. Accordingly, intense efforts to delineate the full complement of signaling pathways mediated by individual receptor subtypes have been pursued. Dopamine D1-like receptors are of particular interest because they are the most abundant dopamine receptors in CNS. Recent work suggests that dopamine signaling could be regulated via dopamine receptor interacting proteins (DRIPs). Unraveling these DRIPs involved in the dopamine system may provide a better understanding of the mechanisms underlying CNS disorders related to dopamine system dysfunction and may help identify novel therapeutic targets.

Dopamine Receptor Interacting Proteins (drips) of Dopamine D1-like Receptors in the Central Nervous System.

S.04.03 Allosteric changes of the NMDA receptor trap diffusible dopamine 1 receptors in spines

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S.04.03 Allosteric changes of the NMDA receptor trap diffusible dopamine 1 receptors in spines