S M Edwards
The Royal Marsden NHS Foundation Trust
10 Papers
188 Citations
S M Edwards is an academic researcher from The Royal Marsden NHS Foundation Trust. The author has contributed to research in topics: Prostate cancer & Germline mutation. The author has an hindex of 10, co-authored 10 publications.
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Papers
Prostate cancer in BRCA2 germline mutation carriers is associated with poorer prognosis
S M Edwards,D G R Evans,Questa Hope,A. R. Norman,Yolanda Barbachano,Sarah Bullock,Z Kote-Jarai,Julia C. Meitz,Alison Falconer,Peter Osin,Cyril Fisher,Michelle Guy,Sameer Jhavar,Amanda L. Hall,Lynne T. O'Brien,Beatrice N. Gehr-Swain,R A Wilkinson,Matthew S. Forrest,David P. Dearnaley,Audrey Ardern-Jones,Elizabeth Page,Doug Easton,Rosalind A. Eeles +22 more
TL;DR: BRCA2 germline mutation is an independent prognostic factor for survival in PrCa and patients with such patients should not be managed with active surveillance as they have more aggressive disease.
•Journal Article
The frequency of germ-line mutations in the breast cancer predisposition genes BRCA1 and BRCA2 in familial prostate cancer. The Cancer Research Campaign/British Prostate Group United Kingdom Familial Prostate Cancer Study Collaborators.
Simon A. Gayther,K A de Foy,Patricia Harrington,P Pharoah,W. D. Dunsmuir,S M Edwards,Cheryl Gillett,Audrey Ardern-Jones,David P. Dearnaley,Doug Easton,D Ford,R. J. Shearer,Roger Kirby,A Dowe,J. Kelly,Michael R. Stratton,Bruce Ponder,Daniel R. Barnes,Rosalind A. Eeles +18 more
TL;DR: In this article, the contribution of BRCA genes to familial prostate cancer was analyzed for gene expression in 38 prostate cancer clusters and two germ-line mutations were found in individuals whose age at diagnosis was very young (< or = 56 years) and who were members of an affected sibling pair.
134
Association between leptin receptor gene polymorphisms and early-onset prostate cancer
Z Kote-Jarai,Rashmi Singh,Francine Durocher,Doug Easton,S M Edwards,Audrey Ardern-Jones,David P. Dearnaley,Richard S. Houlston,Roger Kirby,Rosalind A. Eeles +9 more
TL;DR: The study by Chuang et al. showed that there is also muscular damage during obstruction, specifically of the ureteric myocytes, and for the first time that this induction of cell death is associated with the increased expression of cytochrome c and the caspases, key proteins that drive the induction of apoptosis.
28
No evidence of germline PTEN mutations in familial prostate cancer
Matthew S. Forrest,S M Edwards,Rifat Hamoudi,David P. Dearnaley,Audrey Arden-Jones,A Dowe,A Murkin,J. Kelly,Teare,Doug Easton,Margaret A. Knowles,D T Bishop,Rosalind A. Eeles +12 more
TL;DR: Prostate cancer has an inherited component and linkage studies have not identified chromosome 10 as the site of a predisposing gene, the long arm of chromosome 10 is the fourth commonest region showing loss of heterozygosity in sporadic prostate cancers after 7q, 8p, and 16q.
18
An improved high throughput heteroduplex mutation detection system for screening BRCA2 mutations-fluorescent mutation detection (F-MD).
TL;DR: An improved, fast, automated method for screening large genes such as BRCA2 for germline genomic mutations, based on heteroduplex analysis, which is able to detect single base substitutions that have hitherto only been detectable by direct sequencing methods.