S. Lance Macaulay
Commonwealth Scientific and Industrial Research Organisation
75 Papers
241 Citations
S. Lance Macaulay is an academic researcher from Commonwealth Scientific and Industrial Research Organisation. The author has contributed to research in topics: Glucose transporter & GLUT4. The author has an hindex of 31, co-authored 74 publications. Previous affiliations of S. Lance Macaulay include RMIT University.
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Papers
Amyloid β deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer's disease: a prospective cohort study.
Victor L. Villemagne,Samantha C. Burnham,Pierrick Bourgeat,Belinda M. Brown,Kathryn A. Ellis,Olivier Salvado,Cassandra Szoeke,S. Lance Macaulay,Ralph N. Martins,Paul Maruff,David Ames,Christopher C. Rowe,Colin L. Masters +12 more
TL;DR: These projections suggest a prolonged preclinical phase of AD in which Aβ deposition reaches the authors' threshold of positivity at 17·0 (95% CI 14·9-19·9) years, hippocampal atrophy at 4·2 (3·6-5·1] years, and memory impairment at 3·3 (2·5-4·5) years before the onset of dementia (clinical dementia rating score 1).
2.1K
Interleukin-6 Increases Insulin-Stimulated Glucose Disposal in Humans and Glucose Uptake and Fatty Acid Oxidation In Vitro via AMP-Activated Protein Kinase
Andrew L. Carey,Gregory R. Steinberg,S. Lance Macaulay,Walter G. Thomas,Anna G Holmes,Georg Ramm,Oja Prelovsek,Cordula Hohnen-Behrens,Matthew J. Watt,David E. James,Bruce E. Kemp,Bente Klarlund Pedersen,Mark A. Febbraio +12 more
TL;DR: It is demonstrated that acute IL- 6 treatment enhances insulin-stimulated glucose disposal in humans in vivo, while the effects of IL-6 on glucose and fatty acid metabolism in vitro appear to be mediated by AMPK.
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Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin
Morgan D. Fullerton,Sandra Galic,Katarina Marcinko,Sarah Sikkema,Thomas Pulinilkunnil,Zhi-Ping Chen,Hayley M. O'Neill,Rebecca J. Ford,Rengasamy Palanivel,Matthew L. O'Brien,Matthew L. O'Brien,D. Grahame Hardie,S. Lance Macaulay,Jonathan D. Schertzer,Jason R.B. Dyck,Bryce J. W. van Denderen,Bruce E. Kemp,Bruce E. Kemp,Gregory R. Steinberg,Gregory R. Steinberg +19 more
TL;DR: It is established that inhibitory phosphorylation of Acc by Ampk is essential for the control of lipid metabolism and, in the setting of obesity, for metformin-induced improvements in insulin action.
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Blood-Based Protein Biomarkers for Diagnosis of Alzheimer Disease
James D. Doecke,James D. Doecke,Simon M. Laws,Simon M. Laws,Noel G. Faux,Noel G. Faux,William Wilson,Samantha C. Burnham,Chiou Peng Lam,Alinda Mondal,Alinda Mondal,Justin Bedo,Ashley I. Bush,Ashley I. Bush,Belinda M. Brown,Belinda M. Brown,Karl De Ruyck,Karl De Ruyck,Kathryn A. Ellis,Christopher Fowler,Veer Bala Gupta,Veer Bala Gupta,Richard Head,S. Lance Macaulay,Kelly K. Pertile,Christopher C. Rowe,Alan Rembach,Mark Rodrigues,Mark Rodrigues,Rebecca L. Rumble,Cassandra Szoeke,Kevin Taddei,Kevin Taddei,Tania Taddei,Tania Taddei,Brett Trounson,David Ames,Colin L. Masters,Colin L. Masters,Ralph N. Martins,Ralph N. Martins +40 more
TL;DR: This study identified a panel of plasma biomarkers that distinguish individuals with AD from cognitively healthy control subjects with high sensitivity and specificity.
428
A Role for Protein Kinase Bβ/Akt2 in Insulin-Stimulated GLUT4 Translocation in Adipocytes
Michelle M. Hill,Sharon F. Clark,David F. Tucker,Morris J. Birnbaum,David E. James,S. Lance Macaulay +5 more
TL;DR: It is reported that microinjection of a PKB substrate peptide or an antibody to PKB inhibited insulin-stimulated GLUT4 translocation to the plasma membrane by 66 or 56%, respectively, and support a role for PKBβ in insulin- Stimulated glucose transport in adipocytes.
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