S Jefferies
The Royal Marsden NHS Foundation Trust
5 Papers
7 Citations
S Jefferies is an academic researcher from The Royal Marsden NHS Foundation Trust. The author has contributed to research in topics: Epidermoid carcinoma & Cancer. The author has an hindex of 5, co-authored 5 publications.
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Papers
Genetic mechanisms in squamous cell carcinoma of the head and neck
S Jefferies,William D. Foulkes +1 more
TL;DR: The current advances in understanding of the roles of somatic mutations, viral infection and angiogenesis are discussed and the way in which molecular changes may be used for prevention, early diagnosis and treatment of SCCHN is focused on.
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The role of genetic factors in predisposition to squamous cell cancer of the head and neck
S Jefferies,Rosalind A. Eeles,David E. Goldgar,Roger A'Hern,J. M. Henk,M. E. Gore,Peter Rhys-Evans,D. J. Archer,K Bishop,A Murkin,Ellen Solomon,S Hodgsun,M. O’Connell,J. Hibbert,Doug Easton,William D. Foulkes +15 more
TL;DR: In this paper, the authors defined head and neck cancer as squamous cell carcinoma occurring in the upper aerodigestive tract, superior to the clavicles, excluding skin cancer and nasopharyngeal carcinoma.
Association between polymorphisms of the GPX1 gene and second primary tumours after index squamous cell cancer of the head and neck.
S Jefferies,Z Kote-Jarai,David E. Goldgar,Richard S. Houlston,M.-J. Frazer-Williams,Roger A'Hern,J.M. Henk,Martin Gore,Peter Rhys-Evans,D. J. Archer,K Bishop,Ellen Solomon,Shirley Hodgson,Mark McGurk,J. Hibbert,M. O’Connell,M. Partridge,E. Chevretton,F. Calman,M. Saunders,K. Shotton,A.E. Brown,S. Whittaker,William D. Foulkes +23 more
TL;DR: The results suggest that polymorphisms in the GPX1 gene may be a marker for SPT development and further studies are indicated.
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The accuracy of cancer diagnoses as reported in families with head and neck cancer: a case-control study.
TL;DR: This study highlights the difficulties encountered in confirming cancer diagnoses among first-degree relatives within this cancer site and suggests more robust systems are needed to interlink cancer registries, population data and hospital records.
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No germline mutations in CDKN2A (p16) in patients with squamous cell cancer of the head and neck and second primary tumours.
S Jefferies,S M Edwards,Rifat Hamoudi,Roger A'Hern,William D. Foulkes,David E. Goldgar,Rosalind A. Eeles +6 more
TL;DR: The 3 coding exons of CDKN2A were sequenced in 40 patients who had developed a second primary cancer after an index squamous cell cancer of the head and neck and it is concluded that CD KN2A mutations do not play a major role in cancer susceptibility in this group.