S. J. Lye
University of Western Ontario
23 Papers
357 Citations
S. J. Lye is an academic researcher from University of Western Ontario. The author has contributed to research in topics: Myometrium & Fetus. The author has an hindex of 12, co-authored 23 publications. Previous affiliations of S. J. Lye include St. Joseph Hospital.
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Papers
Early changes in prostaglandin concentrations in ovine maternal and fetal plasma, amniotic fluid and from dispersed cells of intrauterine tissues before the onset of ACTH-induced pre-term labour.
TL;DR: The results imply a causal relationship between rising PG and later myometrial contractions, rather than PG changes resulting from enhanced uterine activity, and there is a selective increase in plasma PGF-2 alpha concentrations before the onset of delivery.
Activation of ovine fetal adrenal function by pulsatile or continuous administration of adrenocorticotropin-(1-24). I. Effects on fetal plasma corticosteroids.
TL;DR: Activation of fetal adrenal function is demonstrable in vivo during P-ACTH administration and is reflected by selective F hypersecretion and may lead to premature delivery.
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Prostanoid concentrations in maternal/fetal plasma and amniotic fluid and intrauterine tissue prostanoid output in relation to myometrial contractility during the onset of adrenocorticotropin-induced preterm labor in sheep.
TL;DR: PGs increase in all fluids before the increase in uterine mechanical activity during induced preterm labor, implying that PGs mediate this event and are not a result of the administration of P-ACTH.
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Myometrial desensitization to continuous but not to intermittent β-adrenergic agonist infusion in the sheep
TL;DR: It is demonstrated that either continuous administration of beta-agonists or intermittent administration of the long-acting beta-agonist ritodrine resulted in myometrial desensitization in the sheep, and intermittentadministration of the short- acting beta-adrenergic agonist isoproterenol prevented the onset of myometric desensITization.
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Modulation by cortisol of adrenocorticotropin-induced activation of adrenal function in fetal sheep.
TL;DR: A role for glucocorticoids in modulating ACTH-induced activation of adrenal function in late gestation fetal sheep is supported, and in vivo treatment with dexamethasone in addition to P-ACTH plus metopirone significantly raised basal outputs of F and S, but the cells were unresponsive to ACTH in vitro.
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