S Hofmann
University of Ulm
5 Papers
27 Citations
S Hofmann is an academic researcher from University of Ulm. The author has contributed to research in topics: Granzyme B & Interleukin 21. The author has an hindex of 3, co-authored 5 publications.
Chat about Author
Papers
Human B cells differentiate into granzyme B-secreting cytotoxic B lymphocytes upon incomplete T-cell help.
Magdalena Hagn,Kai Sontheimer,Karen Dahlke,Sabine Brueggemann,Christof Kaltenmeier,Thamara Beyer,S Hofmann,Oleg Lunov,Thomas F. E. Barth,Dorit Fabricius,Kyrylo Tron,Gerd Ulrich Nienhaus,Gerd Ulrich Nienhaus,Thomas Simmet,Hubert Schrezenmeier,Bernd Jahrsdörfer +15 more
TL;DR: It is shown that in the absence of CD40L, CD4+ T cell‐derived IL‐21 induces differentiation of B cells into granzyme B (GzmB)‐secreting cytotoxic cells, which may have a role in early cellular immune responses including tumor immunosurveillance before fully activated, antigen‐specific cytot toxic T cells are on the spot.
104
Leukemic stem cells of acute myeloid leukemia patients carrying NPM1 mutation are candidates for targeted immunotherapy
Vanessa Schneider,Liling Zhang,Lars Bullinger,Markus Rojewski,S Hofmann,Markus Wiesneth,Hubert Schrezenmeier,Marlies Götz,Ursula Botzenhardt,T F E Barth,Konstanze Döhner,Hartmut Döhner,Jochen Greiner +12 more
TL;DR: Leukemic stem cells of acute myeloid leukemia patients carrying NPM1 mutation are candidates for targeted immunotherapy
23
Strong impact of extramedullary involvement in high-risk AML patients with active disease receiving the FLAMSA conditioning regimen for HSCT
Stephan R Bohl,S von Harsdorf,Medhanie A. Mulaw,S Hofmann,Anna Babiak,C P Maier,J Schnell,L-M Hütter-Krönke,Katrina Scholl,Verena Wais,Richard F. Schlenk,Lars Bullinger,Mark Ringhoffer,Hartmut Döhner,Donald Bunjes,Martin Bommer,Florian Kuchenbauer +16 more
TL;DR: Strong impact of extramedullary involvement in high-risk AML patients with active disease receiving the FLAMSA conditioning regimen for HSCT is found.
•Journal Article
HIV triggers interleukin 21-mediated induction of granzyme B-secreting B cells with antiviral properties
Christof Kaltenmeier,Karen Dahlke,Ali Gawanbacht,S Hofmann,Thamara Beyer,Georg Härter,Beate Grüner,Peter Kern,Frank Kirchhoff,Hubert Schrezenmeier,Bernd Jahrsdörfer +10 more
TL;DR: It is demonstrated that HIV induces IL-21 in CD4+ T cells, thereby indirectly triggering the development of GrB-secreting B cells with antiretroviral properties, which may play a so far unappreciated role in decelerating the expansion of HIV.
1