Pharmacological prevention of post-traumatic stress disorder and acute stress disorder: a systematic review and meta-analysis

Preventing the onset of post traumatic stress disorder.

In 2001, Van den Berghe and colleagues were able to show that tight glucose control decreases morbidity and mortality rates in the intensive care unit (ICU) setting. Several large, prospective, randomized controlled trials have failed to confirm these results. All of these studies attempted tight glucose control using expert-designed algorithms to adjust the rate of intravenous insulin. Unfortunately, these studies each had high rates of hypoglycemia, a high percentage of glucose values outside of the target range, and increased glucose variability. These three measurements have been shown to increase mortality rates in ICU patients. In order to achieve a high rate of success with regards to tight glucose control, a closed-loop system will need to be created. The two main elements of such a system are a continuous glucose sensor and a recursive glucose control algorithm. This review highlights the important elements of the native glucoregulatory system, which, if utilized, may help create a successful glucose control algorithm for a closed-loop system.

/pdf/essential-elements-of-the-native-glucoregulatory-system-djpf03gow3.pdf

Essential Elements of the Native Glucoregulatory System, Which, If Appreciated, May Help Improve the Function of Glucose Controllers in the Intensive Care Unit Setting

Background:Deviations in glucose control in critical care have been shown to increase mortality and morbidity. However, optimal glucose control through present technologies has shown to be a challe...

https://journals.sagepub.com/doi/pdf/10.1177/1932296819832876

Insulin-Based Infusion System: Advancing the Development.

https://www.thelancet.com/pdfs/journals/lanpsy/PIIS2215-0366(14)00121-7.pdf

Luminous Medical (Carlsbad, CA, USA) is developing an automated, patient-attached system that uses near-infrared spectroscopy to measure glucose in whole blood The system under development will aid caregivers in achieving tight glycemic control in critical care patients Luminous Medical conducted a pilot study to characterize system performance in terms of automated blood access and glucose measurement accuracy

/pdf/evaluation-of-a-near-infrared-automated-blood-glucose-1wstn2ealp.pdf

Evaluation of a near-infrared automated blood glucose monitor for use in critical care settings

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Evaluation of a near-infrared automated blood glucose monitor for use in critical care settings