S. Fischer
6 Papers
8 Citations
S. Fischer is an academic researcher. The author has contributed to research in topics: Biology & PRC2. The author has an hindex of 2, co-authored 5 publications.
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Papers
The histone acetyltransferase KAT6A is recruited to unmethylated CpG islands via a DNA binding winged helix domain
Lisa Weber,Yu Jia,Bastian Stielow,Stephen S. Gisselbrecht,Yinghua Cao,Yi Ren,Iris Rohner,Jessica King,Elisabeth Rothman,S. Fischer,Clara Simon,Ignasi Forné,Andrea Nist,Thorsten Stiewe,Martha L. Bulyk,Zhanxin Wang,Robert Liefke +16 more
TL;DR: In this paper , the winged helix (WH) domain at the very N-terminus of KAT6A specifically interacts with unmethylated CpG motifs.
Evolutionary adaptation of the Polycomb repressive complex 2
TL;DR: The Polycomb repressive complex 2 (PRC2) as discussed by the authors is an essential chromatin regulatory complex involved in repressing the transcription of diverse developmental genes, and it consists of a core complex; possessing H3K27 methyltransferase activity and various associated factors that are important to modulate its function.
IRF2BP2 counteracts the ATF7/JDP2 AP-1 heterodimer to prevent inflammatory overactivation in acute myeloid leukemia (AML) cells
S. Fischer,Lisa Weber,Bastian Stielow,Miriam Frech,Clara Simon,Ignasi Forné,Andrea Nist,Uta-Maria Bauer,Thorsten Stiewe,Andreas Neubauer,Robert Liefke +10 more
TL;DR: In this paper , the authors demonstrate that IRF2BP2 interacts with the AP-1 heterodimer ATF7/JDP2, which is involved in activating inflammatory pathways in AML cells.
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Polycomb-like Proteins in Gene Regulation and Cancer
S. Fischer,Robert Liefke +1 more
TL;DR: In this paper , the authors summarize the current understanding of the molecular mechanisms of the polycomb-like proteins (PCLs) and how alterations in their functionality contribute to cancer development and highlight the nonoverlapping and partially opposing roles of the three PCLs in human cancer.
SAMD1 suppresses epithelial-mesenchymal transition (EMT) pathways in pancreatic ductal adenocarcinoma
Clara Simon,Inka D. Brunke,Bastian Stielow,Ignasi Forné,A. Steitz,Merle Geller,Iris Rohner,Lisa Weber,S. Fischer,Lea Marie Jeude,Andrea Nist,Thorsten Stiewe,Magdalena Huber,Malte Buchholz,Robert Liefke +14 more
TL;DR: New insights are provided into the regulation of EMT-related genes in PDAC, shedding light on the intricate role of SAMD1 and its interplay with FBXO11 in this cancer type.