S. E. Serdyuk
Russian Academy
19 Papers
33 Citations
S. E. Serdyuk is an academic researcher from Russian Academy. The author has contributed to research in topics: AMPA receptor & Memantine. The author has an hindex of 5, co-authored 19 publications.
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Papers
Comparative study of preventive and therapeutic effects of IEM-1966 and memantine in rats with experimental allergic encephalomyelitis.
TL;DR: Preventive and therapeutic effects of memantine and IEM-1966, a blocker of both NMDA-and GluR1 AMPA-receptors, on the model of acute experimental allergic encephalomyelitis reduced the severity of neurological disturbances and duration of the disease.
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Combined blockade of NMDA and AMPA receptors prevents acute kainate seizures and chronic kainate lethality in rats.
TL;DR: Intramuscular injection of NBQX, a selective blocker of AMPA receptors (10 mg/kg), produced more pronounced anticonvulsant and neuroprotective effects: it prevented generalized kainate seizures and chronic kainates lethality in 100 and 80% rats, respectively, however, even the high dose ofNBQX prevented the clonic kainATE seizures only in 30% rats.
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Combined blockade of α3β4 nicotinic acetylcholine receptors and GluR1 AMPA receptors in rats prevents kainate-induced tonic-clonic seizures
S. E. Serdyuk,V. E. Gmiro +1 more
TL;DR: Intramuscular injection of IEM-1754, a blocker of cerebral GluR1 AMPA receptors, in doses of 0.5–3.0 mg/kg decreased the incidence of kainate-induced tonic-clonic seizures and mortality rate by 2.7–4 times.
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Epinephrine potentiates the analgesic and antidepressant effects of amitriptyline as a result of stimulation of the gastric mucosal afferents.
S. E. Serdyuk,V. E. Gmiro +1 more
TL;DR: Combined injection of amitriptyline with epinephrine in the threshold doses (ineffective if used alone), 1/10 and 1/30 minimum effective doses, respectively, leads to the development of the maximum analgesic and antidepressant effect, but causes no sedative side effect.
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Comparison of Pharmacological Potency and Safety of Glutamate Blocker IEM-1913 and Memantine
TL;DR: Adamantane-containing glutamate blocker IEM-1913 equals to memantine in antiparkinsonian potency, but surpasses it in anticonvulsive, antidepressant, and analgesic activities, and its use is less toxic and safer.
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