S.E. Moroi
University of Michigan
11 Papers
6 Citations
S.E. Moroi is an academic researcher from University of Michigan. The author has contributed to research in topics: Glaucoma & Genome-wide association study. The author has an hindex of 6, co-authored 11 publications.
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Papers
•Journal Article
Variation in optineurin (OPTN) allele frequencies between and within populations
Ayala-Lugo Rm,Hemant Pawar,David M. Reed,Paul R. Lichter,S.E. Moroi,Page M,James Eadie,Azocar,Maul E,Ntim-Amponsah C,Bromley W,E Obeng-Nyarkoh,Johnson At,Theresa Guckian Kijek,Catherine A. Downs,Jenae M. Johnson,Rodolfo A. Perez-Grossmann,Maria Luisa Guevara-Fujita,Ricardo Fujita,Margaret R. Wallace,Julia E. Richards +20 more
TL;DR: This study contributes additional evidence to support the previously reported association of the OPTN E50K mutation with glaucoma and finds an additional 691_692insAG OPTN variant, but can still only conclude that this variant is rare.
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Systems genetics identifies a role for Cacna2d1 regulation in elevated intraocular pressure and glaucoma susceptibility
Sumana R Chintalapudi,Doaa Nabih Maria,Doaa Nabih Maria,Xiang Di Wang,Jessica N. Cooke Bailey,R. Rand Allingham,Murray H. Brilliant,D. L. Budenz,John H. Fingert,Douglas E. Gaasterland,Terry Gaasterland,Jonathan L. Haines,Lisa A Hark,Michael A. Hauser,Robert P. Igo,Jae H. Kang,Peter Kraft,Richard K. Lee,Paul R. Lichter,Yutao Liu,S.E. Moroi,Louis R. Pasquale,Margaret A. Pericak-Vance,Anthony Realini,Doug Rhee,Julia R. Richards,Robert Ritch,Joel S. Schuman,William K. Scott,Kuldev Singh,Arthur J. Sit,Douglas Vollrath,Gadi Wollstein,Donald J. Zack,Tin Aung,Peter Bonnemaijer,Cheng Yu Cheng,Jamie E Craig,Cornelia M. van Duijn,Puya Gharahkhani,Adriana I. Iglesias Gonzalez,Christopher J Hammond,Alex W. Hewitt,René Hoehn,Fridbert Jonansson,Anthony P Khawaja,Chiea Chuen Khor,Caroline C W Klaver,Andrew J. Lotery,David A. Mackey,Stuart MacGregor,Calvin C P Pang,Francesca Pasutto,Kari Stefansson,Gudmar Thorleifsson,Unnar Thorsteinsdottir,Veronique Vitart,Eranga N. Vithana,Terri L. Young,Tanja Zeller,Pirro G. Hysi,Janey L. Wiggs,Robert W. Williams,Monica M. Jablonski +63 more
TL;DR: The authors identify CACNA2D1 as an IOP risk gene that can be therapeutically targeted by the drug pregabalin in animal models and demonstrate that the systems genetics approach represents an efficient method to identify genetic variation that can guide the selection of therapeutic targets.
Analysis combining correlated glaucoma traits identifies five new risk loci for open-angle glaucoma
Puya Gharahkhani,Kathryn P. Burdon,Jessica N. Cooke Bailey,Alex W. Hewitt,Matthew Law,Louis R. Pasquale,Jae H. Kang,Jonathan L. Haines,Emmanuelle Souzeau,Tiger Zhou,Owen M. Siggs,John Landers,Mona S Awadalla,Shiwani Sharma,Richard A. Mills,Bronwyn Ridge,David J. Lynn,Robert J Casson,Stuart L. Graham,Ivan Goldberg,Andrew White,Paul R. Healey,John R. Grigg,Mitchell Lawlor,Paul Mitchell,Jonathan B Ruddle,Michael Coote,Mark J Walland,Stephen Best,Andrea L Vincent,Jesse Gale,Graham L. Radford-Smith,Graham L. Radford-Smith,David C. Whiteman,Grant W. Montgomery,Grant W. Montgomery,Nicholas G. Martin,David A. Mackey,David A. Mackey,Janey L. Wiggs,Stuart MacGregor,Jamie E Craig,R. Rand Allingham,Murray H. Brilliant,Donald L. Budenz,John H. Fingert,Douglas E. Gaasterland,Terry Gaasterland,Lisa A Hark,Michael A. Hauser,Robert P. Igo,Peter Kraft,Richard K. Lee,Paul R. Lichter,Yutao Liu,S.E. Moroi,Margaret A. Pericak-Vance,Anthony Realini,Doug Rhee,Julia E. Richards,Robert Ritch,Joel S. Schuman,William K. Scott,Kuldev Singh,Arthur J. Sit,Douglas Vollrath,Gadi Wollstein,Donald J. Zack +67 more
TL;DR: This study is the first integrative study to combine genetic data from OAG and its correlated traits to identify new risk variants and genetic pathways, highlighting the future potential of combining geneticData from genetically-correlated eye traits for the purpose of gene discovery and mapping.
Association of a Primary Open-Angle Glaucoma Genetic Risk Score With Earlier Age at Diagnosis.
Baojian Fan,Jessica N. Cooke Bailey,Robert P. Igo,Jae H. Kang,Tahani Boumenna,Murray H. Brilliant,Donald L. Budenz,John H. Fingert,Terry Gaasterland,Douglas E. Gaasterland,Michael A. Hauser,Peter Kraft,Richard K. Lee,Paul R. Lichter,Yutao Liu,S.E. Moroi,Jonathan S. Myers,Margaret A. Pericak-Vance,Anthony Realini,Douglas J Rhee,Julia E. Richards,Robert Ritch,Joel S. Schuman,William K. Scott,Kuldev Singh,Arthur J. Sit,Douglas Vollrath,Robert N. Weinreb,Gadi Wollstein,Donald J. Zack,Jonathan L. Haines,Louis R. Pasquale,Janey L. Wiggs +32 more
TL;DR: A higher dose of POAG risk alleles was associated with an earlier age at glaucoma diagnosis and a GRS that comprised genetic variants associated with POAG could help identify patients with risk of earlier disease onset impacting screening and therapeutic strategies.
Family-based genome-wide association study of south Indian pedigrees supports WNT7B as a central corneal thickness locus
Baojian Fan,Xueli Chen,Nisha Sondhi,P. Ferdinamarie Sharmila,Nagasamy Soumittra,Sarangapani Sripriya,Srinivasan Sacikala,Rashima Asokan,David S. Friedman,Louis R. Pasquale,X. Raymond Gao,Lingam Vijaya,Jessica N. Cooke Bailey,Veronique Vitart,Stuart MacGregor,Christopher J Hammond,Chiea Chuen Khor,Jonathan L. Haines,Ronnie George,Janey L. Wiggs,R. Rand Allingham,Jim Gauderman,Michael A. Hauser,Jerome I. Rotter,Rohit Varma,Tin Aung,Kathryn P. Burdon,Ching-Yu Cheng,Jamie E Craig,Angela J. Cree,Puya Gharahkhani,Alex W. Hewitt,René Höhn,Pirro G. Hysi,Adriana I. Iglesias Gonzalez,Jost B. Jonas,Anthony P Khawaja,Caroline C W Klaver,Francesca Pasutto,David A. Mackey,Paul Mitchell,Aniket Mishra,Calvin C P Pang,Henriette Springelkamp,Gudmar Thorleifsson,Unnur Thorsteinsdottir,Cornelia M. van Duijn,Ananth C. Viswanathan,Robert Wojciechowski,Tien Wong,Terri L. Young,Tanja Zeller,Murray H. Brilliant,D. L. Budenz,John H. Fingert,Douglas E. Gaasterland,Terry Gaasterland,Robert P. Igo,Jae H. Kang,Peter Kraft,Richard K. Lee,Paul R. Lichter,Yutao Liu,S.E. Moroi,Anthony Realini,Doug Rhee,Julia R. Richards,Robert Ritch,Joel S. Schuman,William K. Scott,Kuldev Singh,Arthur J. Sit,Douglas Vollrath,Robert N. Weinreb,Gadi Wollstein,Donald J. Zack +75 more
TL;DR: An ocular phenome-wide association study for the top WNT7B SNPs using 45 ocular traits measured in these same families including corneal curvature and axial length indicates that in the South Indian families WNT6B SNP are primarily associated with CCT, and suggests that W NT7BSNPs can have population-specific effects on ocular quantitative traits.