S. E. Daniel
30 Papers
110 Citations
S. E. Daniel is an academic researcher. The author has contributed to research in topics: Substantia nigra & Progressive supranuclear palsy. The author has an hindex of 23, co-authored 30 publications.
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Papers
Alterations in glutathione levels in Parkinson's disease and other neurodegenerative disorders affecting basal ganglia
Jeswinder Sian,D. T. Dexter,A. J. Lees,S. E. Daniel,Yves Agid,F. Javoy-Agid,Peter Jenner,C. D. Marsden +7 more
TL;DR: The altered GSH/GSSG ratio in the substantia nigra in Parkinson's disease is consistent with the concept of oxidative stress as a major component in the pathogenesis of nigral cell death in Parkinson’s disease.
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Alterations in the levels of iron, ferritin and other trace metals in Parkinson's disease and other neurodegenerative diseases affecting the basal ganglia.
D. T. Dexter,A. Carayon,F. Javoy-Agid,Yves Agid,F. R. Wells,S. E. Daniel,A. J. Lees,Peter Jenner,C. D. Marsden +8 more
TL;DR: An increase in total iron content appears to be a response to neurodegeneration in affected basal ganglia regions in a number of movement disorders, suggesting an alteration of iron handling in the substantia nigra in PD.
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Multiple system atrophy: A review of 203 pathologically proven cases
TL;DR: Characteristic glial and/or neuronal cytoplasmic inclusions were identified in all cases in which they were sought, irrespective of clinical presentation, and an association of postural hypotension with intermediolateral cell column degeneration was confirmed.
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Increased levels of lipid hydroperoxides in the parkinsonian substantia nigra: An HPLC and ESR study
D. T. Dexter,A. E. Holley,W.D. Flitter,T. F. Slater,F. R. Wells,S. E. Daniel,A. J. Lees,Peter Jenner,C. D. Marsden +8 more
TL;DR: The increased levels of an early component of the peroxidation chain in substantia nigra in Parkinson's disease support the hypothesis of a continuous toxic process involving oxygen radical activity and evidence for increased radical formation could not be demonstrated.
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What clinical features are most useful to distinguish definite multiple system atrophy from Parkinson's disease?
TL;DR: Predictive models may help differentiate MSA and PD premortem and poorly recognised features, suggestive of MSA, included preserved cognitive function and absence of psychiatric effects from antiparkinsonian medication.
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