S E Cross
University of Oxford
14 Papers
24 Citations
S E Cross is an academic researcher from University of Oxford. The author has contributed to research in topics: Islet & Collagenase. The author has an hindex of 9, co-authored 14 publications. Previous affiliations of S E Cross include John Radcliffe Hospital & University of Bristol.
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Papers
Metformin, but not leptin, regulates AMP-activated protein kinase in pancreatic islets: impact on glucose-stimulated insulin secretion
Isabelle Leclerc,Wolfram W. Woltersdorf,Gabriela da Silva Xavier,Rebecca Rowe,S E Cross,Greg Korbutt,Ray V. Rajotte,Richard G. Smith,Guy A. Rutter +8 more
TL;DR: It is demonstrated that AMPK activity is subject to regulation by both glucose and metformin in pancreatic islets and clonal beta-cells and may need to be considered with respect to the use of this drug for the treatment of type 2 diabetes.
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Key Matrix Proteins Within the Pancreatic Islet Basement Membrane Are Differentially Digested During Human Islet Isolation
S E Cross,S E Cross,R H Vaughan,R H Vaughan,A.J. Willcox,A.J. Willcox,A.J. McBride,A.J. McBride,Anju Abraham,Anju Abraham,Bing Han,J D Johnson,J D Johnson,Elisa Maillard,Elisa Maillard,P A Bateman,P A Bateman,Reshma Ramracheya,Patrik Rorsman,Karl E. Kadler,Mark J. Dunne,Stephen J. Hughes,Stephen J. Hughes,Paul Johnson,Paul Johnson +24 more
TL;DR: Islet function and survival may be compromised as a consequence of an incomplete islet BM, which has implications for islet survival and transplanted graft longevity.
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β Cell Replacement Therapy: The Next 10 Years.
Christian Schuetz,Takayuki Anazawa,S E Cross,Leticia Labriola,Raphael P. H. Meier,Robert R. Redfield,Hanne Scholz,Peter G. Stock,Nathan W. Zammit +8 more
TL;DR: An international group of young investigators debated which modality of &bgr; cell replacement would predominate the landscape in 10 years, and their arguments are summarized here.
Sirolimus Toxicity and Vascular Endothelial Growth Factor Release From Islet and Renal Cell Lines
Matthew Laugharne,S E Cross,Sarah K. Richards,Charlotte Dawson,Laura Ilchyshyn,Moin A. Saleem,Peter W. Mathieson,Richard S. Smith +7 more
TL;DR: Data from this study are consistent with the hypothesis that sirolimus is toxic to islets and beta-cells by blockade of VEGF-mediated survival pathways.
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Altered Phenotype of β-Cells and Other Pancreatic Cell Lineages in Patients With Diffuse Congenital Hyperinsulinism in Infancy Caused by Mutations in the ATP-Sensitive K-Channel
Rachel J. Salisbury,Bing Han,Rachel E. Jennings,Rachel E. Jennings,Andrew Berry,Adam Stevens,Adam Stevens,Zainab Mohamed,Zainab Mohamed,Sarah A. Sugden,Ronald R. de Krijger,S E Cross,Paul P.V. Johnson,Melanie Newbould,Karen E. Cosgrove,Karen Piper Hanley,Indraneel Banerjee,Indraneel Banerjee,Mark J. Dunne,Neil A. Hanley,Neil A. Hanley +20 more
TL;DR: New molecular abnormalities in δ-cells and marked proliferative increases in other pancreatic lineages indicate CHI-D is not solely a β-cell disorder, but with G1/S molecules positioned in favor of cell cycle progression.
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