Application of the digital volume correlation technique for the measurement of displacement and strain fields in bone: A literature review

3D-printed PLA/HA composite structures as synthetic trabecular bone: a feasibility study using Fused Deposition Modelling

3D-printed PLA/HA composite structures as synthetic trabecular bone: A feasibility study using fused deposition modeling.

Bone reconstruction techniques are mainly based on the use of tissue grafts and artificial scaffolds. The former presents well-known limitations, such as restricted graft availability and donor site morbidity, while the latter commonly results in poor graft integration and fixation in the bone, which leads to the unbalanced distribution of loads, impaired bone formation, increased pain perception, and risk of fracture, ultimately leading to recurrent surgeries. In the past decade, research efforts have been focused on the development of innovative bone substitutes that not only provide immediate mechanical support, but also ensure appropriate graft anchoring by, for example, promoting de novo bone tissue formation. From the countless studies that aimed in this direction, only few have made the big jump from the benchtop to the bedside, whilst most have perished along the challenging path of clinical translation. Herein, we describe some clinically successful cases of bone device development, including biological glues, stem cell-seeded scaffolds, and gene-functionalized bone substitutes. We also discuss the ventures that these technologies went through, the hindrances they faced and the common grounds among them, which might have been key for their success. The ultimate objective of this perspective article is to highlight the important aspects of the clinical translation of an innovative idea in the field of bone grafting, with the aim of commercially and clinically informing new research approaches in the sector.

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The Few Who Made It : Commercially and Clinically Successful Innovative Bone Grafts

The discrete nature of trabecular bone microarchitecture affects implant stability

Screw insertion in trabecular bone causes peri-implant bone damage.

Time-lapsed imaging of implant fixation failure in human femoral heads

Peri-implant bone microstructure determines dynamic implant cut-out.

Peri-implant bone microstructure determines dynamic implant cut-out

Micro-finite element (μFE) analysis has recently been introduced for the detailed quantification of the mechanical interaction between bone and implant The technique has been validated at an apparent level The aim of this study was to address the accuracy of μFE analysis at the trabecular level Experimental displacement fields were obtained by deformable image registration, also known as strain mapping (SM), of dynamic hip screws implanted in three human femoral heads In addition, displacement fields were calculated using μFE analysis On a voxel-by-voxel basis, the coefficients of determination (R(2)) between experimental and μFE-calculated displacements ranged from 067 to 092 Linear regression of the mean displacements over nine volumes of interest yielded R(2) between 081 and 084 The lowest R(2) values were found in regions of very small displacements In conclusion, we found that peri-implant bone displacements calculated with μFE analysis correlated well with displacements obtained from experimental SM

Towards validation of computational analyses of peri-implant displacements by means of experimentally obtained displacement maps

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Time-lapsed imaging of implant fixation failure in human femoral heads

Peri-implant bone microstructure determines dynamic implant cut-out.

Peri-implant bone microstructure determines dynamic implant cut-out

Towards validation of computational analyses of peri-implant displacements by means of experimentally obtained displacement maps