S. E. Barker
UCL Institute of Ophthalmology
18 Papers
61 Citations
S. E. Barker is an academic researcher from UCL Institute of Ophthalmology. The author has contributed to research in topics: Gene delivery & Biology. The author has an hindex of 15, co-authored 18 publications. Previous affiliations of S. E. Barker include University College London & Oregon Health & Science University.
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Papers
Long-Term Effect of Gene Therapy on Leber’s Congenital Amaurosis
James W B Bainbridge,James W B Bainbridge,Manjit S Mehat,Venki Sundaram,Scott J Robbie,S. E. Barker,Caterina Ripamonti,Anastasios Georgiadis,Anastasios Georgiadis,Freya M. Mowat,Freya M. Mowat,Stuart G Beattie,Peter Gardner,Kecia L. Feathers,Vy Luong,Suzanne Yzer,Kamaljit S. Balaggan,Kamaljit S. Balaggan,Ananth C. Viswanathan,Thomy de Ravel,Ingele Casteels,Graham E. Holder,Nick Tyler,Fred W. Fitzke,Richard G. Weleber,Marko Nardini,Marko Nardini,Anthony T. Moore,Anthony T. Moore,Debra A. Thompson,Simon M. Petersen-Jones,Michel Michaelides,Michel Michaelides,L. Ingeborgh van den Born,Andrew Stockman,Alexander J. Smith,Gary S. Rubin,Robin R. Ali,Robin R. Ali +38 more
TL;DR: In dogs, RPE65 gene therapy with the same vector at lower doses improved vision-guided behavior, but only higher doses resulted in improvements in retinal function that were detectable with the use of ERG, and comparison with the results obtained in the dog model indicates that there is a species difference in the amount of R PE65 required to drive the visual cycle.
Effective gene therapy with nonintegrating lentiviral vectors
Rafael J. Yáñez-Muñoz,Rafael J. Yáñez-Muñoz,Rafael J. Yáñez-Muñoz,Kamaljit S. Balaggan,A MacNeil,Steven J. Howe,Manfred Schmidt,Manfred Schmidt,Alexander J. Smith,Prateek K. Buch,Robert E MacLaren,Patrick N. Anderson,S. E. Barker,Yanai Duran,CC Bartholomae,CC Bartholomae,Christof von Kalle,John R. Heckenlively,Christine Kinnon,Robin R. Ali,Adrian J. Thrasher +20 more
TL;DR: The high efficiency of gene transfer and expression mediated by lentiviruses can be harnessed in vivo without a requirement for vector integration and substantially reduces the risk of insertional mutagenesis.
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The Drusenlike Phenotype in Aging Ccl2-Knockout Mice Is Caused by an Accelerated Accumulation of Swollen Autofluorescent Subretinal Macrophages
Ulrich F O Luhmann,Scott J Robbie,Peter M. G. Munro,S. E. Barker,Yanai Duran,Vy Luong,Fred W. Fitzke,James W B Bainbridge,Robin R. Ali,Robert E MacLaren +9 more
TL;DR: The findings suggest that the lack of Ccl2 leads to a monocyte/macrophage-trafficking defect during aging and to an impaired recruitment of these cells to sites of laser injury.
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Assessment of ocular transduction using single-stranded and self-complementary recombinant adeno-associated virus serotype 2/8.
M. Natkunarajah,P Trittibach,Jenny McIntosh,Yanai Duran,S. E. Barker,Alexander J. Smith,Amit C. Nathwani,Robin R. Ali +7 more
TL;DR: Improved transduction efficiency of the novel serotype AAV2/8 might facilitate the development of improved gene therapy protocols for inherited retinal degenerations, particularly those caused by defects in photoreceptor-specific genes.
151
Local Administration of an Adeno-associated Viral Vector Expressing IL-10 Reduces Monocyte Infiltration and Subsequent Photoreceptor Damage during Experimental Autoimmune Uveitis
Cathryn A Broderick,Alexander J. Smith,Kam S. Balaggan,Anastasios Georgiadis,Prateek K. Buch,P. Trittibach,S. E. Barker,G.–M. Sarra,Adrian J. Thrasher,Andrew D. Dick,Robin R. Ali,Robin R. Ali +11 more
TL;DR: It is reported for the first time that subretinal injection of rAAV-2 encoding murine IL-10 into the retina of C57BL/6 mice significantly decreases the median experimental autoimmune uveitis (EAU) disease severity.
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