Die spezifischen Aktivitaten der DNS-abhangigen RNS-Polymerasen A und B wurden in von exogener Matrizen-DNS abhangiger Form bei verschiedenen Hamoblastosen bestimmt. Die Aktivitatsbestimmungen erfolgten in Kernhomogenaten isolierter mononuclearer oder segmentkerniger Leukocyten. Eine signifikante Erhohung der Polymeraseaktivitaten A und B fand sich in den Kernhomogenaten mononuclearer Zellen bei akuter myeloischer Leukamie, wahrend diese bei chronisch-myeloischer Leukamie (signifikant) und chronisch-lymphatischer Leukamie (nicht signifikant) erniedrigt waren. Unter cytostatischer Therapie findet sich eine Angleichung der Polymeraseaktivitaten an den Normbereich. Hiermit ergeben sich moglicherweise neue Kriterien zur Verlaufsbeurteilung von Hamoblastosen unter einer Polychemotherapie.

DNS-abhängige RNS-Polymerasen in menschlichen Leukocyten

http://link.springer.com/content/pdf/10.1007/BF01469057.pdf

DNS-abhngige RNS-Polymerasen in menschlichen Leukocyten: II. Unterschiedliche spezifische Aktivitten der Polymerasen A und B bei akuten und chronischen Hmoblastosen und ihre mgliche prognostische Bedeutung

Specific Activities of DNA-dependent RNA polymerases A and B have been determined in nuclei from leukocytes in acute and chronic leukemia. Enzyme activities, dependent on exogenous DNA template, were determined in homogenates of nuclei from isolated mononuclear cells or from isolated granulocytes. Activities of polymerases A and B have been found significantly elevated in homogenates of nuclei from mononuclear cells in acute myelocytic leukemia, while they were found subnormal in corresponding cell fractions from chronic myelocytic leukemia and chronic lymphatic leukemia. During cytostatic treatment polymerase activities were approaching normal values. The prognostic relevance of these data for the course of human leukemia is discussed.

[DNA-dependent RNA polymerases in human leukocytes. II different specific activities of the polymerases A and B in acute and chronic leukemia and their prognostic relevance (author's transl)].

Wir haben uns in den letzten Jahren mit der Friend-Virus induzierten Erythroleukamie bei der Maus beschaftigt. Bei dieser werden sowohl abnormal differenzierte Zellen der roten, wie der lymphatischen Reihe gefunden. Deshalb lag nahe, diese multiple Differenzierungsentgleisung auf eine abnormale Vermehrung der gemeinsamen Stammzelle nach Transformation dieser Zelle durch das Friend-Virus zuruckzufuhren. In der Folgezeit zeigten aber verschiedene Autoren [1], das zwei Tumorviren, die nur in ihrer Vermehrung voneinander abhangig sind, unabhangig zwei verschiedene Zelltypen transformieren: Das lymphatische Leukamievirus (LLV) transformiert Zellen, die sich lymphatisch und das spleen focus forming-Virus (SFFV) solche, die sich erythroid differenzieren.

Untersuchungen zur Erythropoese bei erythroleukämischen Zellkulturen

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Untersuchungen zur Erythropoese bei erythroleukämischen Zellkulturen