S. Downes
University of Nottingham
35 Papers
1K Citations
S. Downes is an academic researcher from University of Nottingham. The author has contributed to research in topics: Methacrylate & Polymer. The author has an hindex of 24, co-authored 35 publications. Previous affiliations of S. Downes include Smith & Nephew.
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Papers
Biodegradable polymer/hydroxyapatite composites: Surface analysis and initial attachment of human osteoblasts
Simone C. Rizzi,Deborah Heath,Allan G.A. Coombes,Allan G.A. Coombes,N. Bock,Marcus Textor,S. Downes,S. Downes +7 more
TL;DR: Results suggest that PLA and PCL and their composites with HA may be candidate materials for the reconstruction of bony tissue and the effects of acidic degradation products from the biodegradable polymers are required to confirm their utility.
317
Growth of human osteoblast‐like cells on alkanethiol on gold self‐assembled monolayers: The effect of surface chemistry
TL;DR: Primary human osteoblasts were cultured on self-assembled monolayers of alkylthiols on gold with carboxylic acid and methyl termini, and the kinetics of cell attachment and proliferation were measured.
125
Biocomposites of non-crosslinked natural and synthetic polymers.
TL;DR: Investigations of the attachment and spreading characteristics of human osteoblast (HOB) cells on PCL films and collagen:PCL materials respectively, indicated that HOB cells poorly recognised PCL but attachment andSpread were much improved on the biocomposites.
121
Osteoblast responses to collagen-PVA bioartificial polymers in vitro: the effects of cross-linking method and collagen content
TL;DR: There was an inverse relationship between collagen content of gluataraldehyde cross-linked films and the extent of cell proliferation on them, and the DHT cross-link method is a preferable alternative to the use of glutaraldehyde.
119
Regulation of cell surface tissue transglutaminase: effects on matrix storage of latent transforming growth factor-beta binding protein-1
TL;DR: It is concluded that regulation of tTgase expression is important for controlling matrix storage of latent TGF-β1 complexes and that fibronectin may be one extracellular component to which LTBP-1 is crosslinked when LT BP-1 and tTGase interact at the cell surface.
118